摘要
目的探讨表皮生长因子受体(EGFR)基因突变与肺腺癌临床特点的关系。方法收集2017年1月至2019年1月于郑州大学第一附属医院经手术切除(肺段切除、楔形切除术或肺叶切除术)病理诊断为肺腺癌患者194例的临床资料,分析肺腺癌患者性别、年龄、吸烟史、肿瘤标志物、肺腺癌病理分型、切除病灶的分化程度与EGFR基因突变之间的关系,进一步寻找预测EGFR突变的因素。结果194例肺腺癌患者,EGFR基因突变型120例(61.86%),194例中女性EGFR基因突变率高于男性(χ2=10.746,P=0.001),年龄≥60岁者的基因突变率高于<60岁者(χ2=4.111,P=0.043),吸烟者EGFR基因突变率高于非吸烟者(χ2=10.275,P=0.001),肿瘤标志物水平异常者与正常者的EGFR基因突变率差异未见统计学意义(P>0.05)。肺腺癌病理分型中,腺泡为主型者占比较高(63.9%,124/194),其余依次为实性为主型、乳头为主型、贴壁为主型、黏液腺癌;肺腺癌病理分型、切除病灶的分化程度与EGFR基因突变有相关性(χ2=10.275、17.131,P=0.001、0.001)。EGFR突变型中以19、21外显子较多,且病理分型与19、21外显子突变有相关性(χ2=18.613,P=0.001)。结论EGFR基因突变与性别、年龄、吸烟史、主要病理类型、肿瘤分化程度相关,而与肿瘤标志物的水平无关,19、21外显子突变与主要病理类型相关。
Objective To investigate the relationship between the gene mutation of epidermal growth factor receptor (EGFR) and the clinical characteristics of lung adenocarcinoma.Methods The clinical data of 194 patients with lung adenocarcinoma diagnosed by surgical resection (pulmonary resection, wedge resection, or lobectomy) in the First Affiliated Hospital of Zhengzhou University from January 2017 to January 2019 were collected. The relationship between EGFR gene mutation and clinicopathological characteristics including sex, age, smoking history, tumor markers, adenocarcinoma pathological classification, extent of differentiation in patients with lung adenocarcinoma were analyzed, further searched for factors that predicted the mutations of EGFR.Results In the 194 patients with lung adenocarcinoma, there were 120 cases (61.86%) with EGFR gene mutation, the mutation rate of female was higher than that of male (χ2=10.746, P=0.001), the mutation rate of EGFR gene in patients of age≥60 was higher than that in patients of age<60 (χ2=4.111, P=0.043), the mutation rate of EGFR gene in non-smoking patients was higher than that in smoking patients (χ2=10.275, P=0.001), and there was no significant difference in mutation rate of EGFR between normal patients and patients with abnormal tumor markers(P>0.05). Among the main pathological types of lung adenocarcinoma, the proportion of acinar type was the highest in EGFR mutation group(63.9%, 124/194), the others were solid type, papillary type, adherent type, mucinous adenocarcinoma, the differences between the main pathological types and EGFR gene mutation, the differentiation degree of each excised lesion were statistically significant (χ2=10.275, 17.131;P=0.001, 0.001). There were more exons 19 and exon 21 in EGFR mutants, further analysis showed that there was significant difference between different pathological sub-types and mutations of exon 19 and exon 21(χ2=18.613, P=0.001).Conclusions EGFR gene mutation is related to sex, age, smoking history, main pathological type
作者
苗裔
高鑫
郑雅文
赵志远
刘莹
Miao Yi;Gao Xin;Zheng Yawen;Zhao Zhiyuan;Liu Ying(Fifth Department of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用医刊》
2020年第4期8-11,共4页
Chinese Journal of Practical Medicine
基金
河南省高等学校重点科研项目(187310028)。
关键词
肺腺癌
表皮生长因子
受体
病理学
Lung adenocarcinoma
Epidermal growth factor
Receptor
Pathology
