摘要
目的分析大剂量他汀药物对冠心病合并肾功能不全患者肾功能、血管内皮功能、炎性因子水平的影响。方法抽取焦作市第二人民医院2015年1月至2018年12月收治的60例冠心病合并肾功能不全患者,经随机数字表法分为对照组与研究组,每组30例。对照组接受常规剂量瑞舒伐他汀治疗,研究组接受大剂量的瑞舒伐他汀治疗。比较两组患者肾功能、血管内皮功能、炎性因子水平、不良反应发生情况。结果两组患者治疗前24 h尿蛋白、血肌酐水平比较差异未见统计学意义(P>0.05);治疗后,两组24 h尿蛋白、血肌酐水平降低,且研究组水平低于对照组(P<0.05)。两组患者治疗前同型半胱氨酸(HCy)、一氧化氮(NO)、一氧化氮合酶(eNOS)水平比较差异未见统计学意义(P>0.05);治疗后,两组HCy水平降低,NO、eNOS水平升高,且研究组患者HCy水平低于对照组,NO、eNOS水平高于对照组(P<0.05)。治疗前,两组患者白细胞介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)水平比较差异未见统计学意义(P>0.05);治疗后,两组IL-6及MMP-9水平降低,且研究组患者IL-6、MMP-9水平低于对照组(P<0.05)。研究组患者不良反应发生率(33.33%,10/30)高于对照组(26.67%,8/30),但差异未见统计学意义(P>0.05)。结论大剂量他汀药物既能明显改善冠心病合并肾功能不全患者肾功能、血管内皮功能,抑制炎性因子释放,且不增加不良反应发生率。
Objective To analyze the effects of large dose of rosuvastatin on renal function,vascular endothelial function and levels of inflammatory factor in patients with coronary heart disease complicated with renal insufficiency.Methods Sixty patients with coronary heart disease complicated with renal insufficiency admitted to the Second People’s Hospital from January 2015 to December 2018 were randomly divided into the control group and study group by random number table method,with 30 patients in each group.Patients in the control group were treated with conventional dose of rosuvastatin,and patients in the study group were treated with large dose of rosuvastatin.The renal function,vascular endothelial function,levels of inflammatory factor and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in 24 h urinary protein or serum creatinine between the two groups before treatment(P>0.05);after treatment,the levels of 24 h urinary protein and serum creatinie decreased in both groups,and the study group had higher 24 h urinary protein level than the control group(P<0.05).There was no significant difference in homocysteine(Hcy),NO or nitric oxide synthase(eNOS)levels between the two groups before treatment(P>0.05).After treatment,Hcy levels decreased,but NO and eNOS levels increased in both groups;compared to control group,and the Hcy levels in the study group were lower,while NO and eNOS levels were higher(P<0.05).There was no significant difference in the levels of IL-6 or MMP-9 between the two groups before and after treatment(P>0.05).The incidence of adverse reaction of the study group was 33.33%(10/30),higher than the 26.67%(8/30)of the control group,but there was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusions Large dose of rosuvastatin in the treatment of patients with coronary heart disease and renal insufficiency can significantly improve renal function and vascular endothelial function,and reduce i
作者
侯爱琴
李文国
薛鸿群
Hou Aiqin;Li Wenguo;Xue Hongqun(Department of Cardiovascular Medicine,the Second People’s Hospital of Jiaozuo,Jiaozuo 454000,China)
出处
《中国实用医刊》
2020年第5期103-105,共3页
Chinese Journal of Practical Medicine
关键词
大剂量
他汀药物
冠心病
肾功能不全
肾功能
血管内皮功能
炎性因子
Large dose
Statins
Coronary heart disease
Renal insufficiency
Renal function
Vascular endothelial function
Inflammatory factors
