摘要
目的系统评价益生菌对改善抑郁情绪的作用,为抑郁发作的益生菌治疗提供循证参考。方法系统检索PubMed、Embase、中国知网、万方数据库、维普数据库,纳入关于益生菌改善抑郁情绪的随机对照研究(RCT),由两位研究者进行文献筛选并提取数据。采用Stata 16.0进行Meta分析、敏感性检验及发表偏倚检验,并基于评价工具、抑郁类型及年龄分组进行亚组分析。结果本研究共纳入17项研究,包括1192例研究对象。随机效应模型分析结果显示,使用益生菌后,治疗组量表评分变化值优于对照组,差异有统计学意义(SMD=-0.50,95%CI:-0.80^-0.21,Z=3.31,P<0.01)。按照抑郁类型分组的亚组分析中,合并抑郁组、健康组的治疗组与对照组相比差异有统计学意义(合并抑郁组SMD=-0.33,95%CI:-0.63~0.04,Z=2.21,P=0.03;健康组SMD=-0.67,95%CI:-1.09^-0.24,Z=3.07,P<0.01);以年龄分组的亚组分析中,青年组中治疗组与对照组相比差异有统计学意义(SMD=-0.50,95%CI:-0.81^-0.19,Z=3.18,P<0.01)。结论益生菌对抑郁情绪有一定缓解作用,但其效果受患者年龄、是否合并疾病等多方面的影响。
Objective To provide evidence-based references for probiotics treatment of depression,the efficacy of probiotics on depression is systematically evaluated in this paper.Methods Based on PubMed,Embase,CNKI,Wanfang database,VIP database and other systematic retrievals,the randomized controlled study of probiotics to suppress depression was conducted with two researchers working on literature selection and data extraction.Meta-analysis,sensitivity test and publication bias test were performed using Stata 16.0,and subgroup analysis was conducted based on the assessment tool,depression type and age grouping.Results A total of 17 RCTs(n=1192)were included.The analysis of random effects models showed after using probiotics,the score changes in the scale of the experimental group was proved to be better than those of the control group,which was statically significant(SMD=-0.50,95%CI:-0.80^-0.21,Z=3.31,P<0.01).The subgroup analysis by depression type indicates statistically significant differences between the experimental group and the control group in the depression combined diseases group and the healthy group(depression combined diseases group SMD=-0.33,95%CI:-0.63~0.04,Z=2.21,P=0.03;healthy group SMD=-0.67,95%CI:-1.09^-0.24,Z=3.07,P<0.01).In the subgroup analysis grouped by age,the difference between the experimental group and the control group of the youth group was statistically significant(SMD=-0.50,95%CI:-0.81^-0.19,Z=3.18,P<0.01).Conclusion Probiotics can alleviate depression to some extent,but the efficacy is affected by patients’age and whether they have combined diseases or not.
作者
段昌嵘
妙炜
高子丹
冷欢
朱祥路
Duan Changrong;Miao Wei;Gao Zidan;Leng Huan;Zhu Xianglu(Guizhou Medical University,Guiyang 550004,China)
出处
《四川精神卫生》
2020年第3期249-256,共8页
Sichuan Mental Health
基金
贵州省科技厅联合基金项目(项目名称:抗抑郁药物对胃粘膜的保护作用,项目编号:黔科合LH字[2014]7109)。
