摘要
胃肠道是重症患者应激的中心器官和多器官功能障碍综合征的启动器官。急性胃肠损伤时肠黏膜屏障破坏,同时肠道微环境改变引起肠道菌群紊乱,肠道细菌和毒素大量移位,诱发和加重全身炎症反应,导致包括心血管系统在内的多器官功能障碍。本文就肠与心交互作用的相关研究进展进行综述。
The gastrointestinal tract is the central organ of stress,and it is the initially involved organ of the multiple organ dysfunction syndrome.When acute gastrointestinal injury occurs,the gut mucosal barrier is damaged and the intestinal flora is also altered due to the change of gut microenvironment,which together leads to bacterial translocation and endotoxemia,and thus induces and exacerbates systemic inflammatory response syndrome,ultimately resulting in multiple organ dysfunction,including the cardiovascular system.This article reviews the progress in the understanding of the relationship between acute gastrointestinal injury and cardiovascular disease.
作者
张李迪
陈德昌
Zhang Lidi;Chen Dechang(Department of Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华重症医学电子杂志》
2020年第2期143-145,共3页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
基金
国家自然科学基金项目(81571943,81873944)。
关键词
急性胃肠损伤
心力衰竭
急性冠脉综合征
Acute gastrointestinal injury
Heart failure
Acute coronary syndrome
