摘要
目的探讨沈阳地区手足口病病原体分布及流行特征,为手足口病的防控和临床诊治提供参考依据。方法采用描述性流行病学方法,对2014—2018年中国医科大学附属盛京医院就诊的手足口病患儿病例信息及病原学监测数据进行分析。结果共接诊临床诊断手足口病患儿25571例,17263例(67.51%)肠道病毒检测阳性,其中男患儿阳性检出率为69.72%(10305/14780),女患儿阳性检出率为64.48%(6958/10791),男女患儿阳性检出率比较,差异有统计学意义(χ2=78.167,P<0.001)。手足口病肠道病毒检测阳性患儿中,<6岁者占92.59%,其中3~岁年龄组占比最高(24.53%)。手足口病全年均有发病,但季节分布明显,呈单峰状分布,每年7、8月份最高,占比为29.94%~52.30%。手足口病分离病原体EV-71占12.71%,CV-A16占24.38%,其他肠道病毒占62.91%。结论除EV-71和CV-A16外沈阳地区手足口病患儿感染其他肠道病毒所占比例较高,每年7、8月份为手足口病高发期,以<6岁的儿童发病为主,男孩发病居多。
Objective To explore pathogenic distribution and epidemic characteristics of hand,foot and mouth disease(HFMD)in Shenyang area,and provide reference for prevention and control as well as clinical diagnosis and treatment for HFMD.Methods Descriptive epidemiological method was used to analyze information and pathogenic monitoring data of HFMD children in Shengjing Hospital Affiliated to China Medical University from 2014 to 2018.Results There were 25571 cases of HFMD,17263(67.51%)were positive for enterovirus,positive rates in boys and girls were 69.72%(10305/14780)and 64.48%(6958/10791)respectively,positive rate between boys and girls was statistically significant(χ2=78.167,P<0.001).Among children with positive detection result of HFMD enterovirus,92.59%were<6 years old,the highest proportion was in the 3-year old group(24.53%).HFMD occurred all year round,but seasonal distribution was obvious,showing a single peak distribution,the highest was in July and August every year,accounting for 29.94%-52.30%.Among pathogens isolated from children with HFMD,EV-71 and CV-A16 accounted for 12.71%and 24.38%respectively,other enterovirus was 62.91%.Conclusion Except EV-71 and CV-A16,other enterovirus causing HFMD in children in Shenyang area are high,July and August every year are peak season,HFMD mainly occurs in children<6 years old,especially boys.
作者
齐特
黄郁晶
吉耀华
王博
苗野
刘超
吴昊
阮强
QI Te;HUANG Yu-jing;JI Yao-hua;WANG Bo;MIAO Ye;LIU Chao;WU Hao;RUAN Qiang(Virus Research Laboratory, Shengjing Hospital of China Medical University, Shen -yang 110000, China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2020年第7期648-652,共5页
Chinese Journal of Infection Control
关键词
手足口病
肠道病毒属
病原菌
流行特征
hand,foot and mouth disease(HFMD)
enterovirus
pathogen
epidemic characteristic
