摘要
目的分析2017-2018年黑龙江省老年活动性肺结核流行及耐药性特征,为老年结核防治工作提供基础数据。方法分别从性别、职业、学历、收入、医疗保障、居住地、吸烟饮酒习惯等方面分析黑龙江省1 045例60岁以上老年肺结核患者的分布特点;对326株菌株培养呈阳性的进行菌种鉴定,并对INH、SM、 EMB、RFP、OFX、KM 6种药物进行敏感性试验。采用χ^2检验进行比较,以P<0.05为差异有统计学意义。结果 2017-2018年老年肺结核患者人数占总就诊患者的31.33%(1 045/3 335),其中男性患者为女性患者的2.18倍(716/329),农民、文化程度低、收入低、有吸烟饮酒习惯者为老年肺结构主要患病人群。菌株培养结果显示,325株(99.69%)为结核分枝杆菌复合群菌株,240人对药物敏感,85人有耐药性,6种药物耐药顺序为SM (16.26%)>RFP(9.20%)>INH(9.20%)>OFX(7.06%)>EMB(3.68%)>KM(2.15%)。结论应对老年肺结核患者高危人群进行重点监控,并制定相关的干预措施。
Objective To analyze the distribution characteristics and drug resistance of tuberculosis patients in the elderly group in Heilongjiang from 2017 to 2018,provide foundation database for comparing tuberculosis in the elderly group in China.Methods One thousand and forty-five patients over 60 years old with tuberculosis were researched in Heilongjiang from 2017 to 2018.The lung tuberculosis patients were analyzed for gender,occupation,education,income,medical security,place of residence,smoking and drinking habits.Three hundred and twenty-six strains were obtained for strain identification and INH,SM,EMB,RFP,OFX,KM,6 drug resistance tests.Chi-square test was used to analyze.P<0.05 was considered to be statistically significant.Results During 2017 and 2018,the incidence in the elderly group accounted for 31.33% of the total number of people(1 045/3 335);the number of male patients was about 2.18 times than that of female patients(716/329).Living in rural areas,farmers’ occupation,low education level with low incomes and smoking and drinking habits were susceptible to elder tuberculosis.During 2017 and 2018,there were a total of 325 strains(99.69%) in Heilongjiang of M.tuberculosis complex strains,of which 240 were sensitive and 85 were resistant.The order of drug resistance of 6 that SM(16.26%)>RFP(9.20%)>INH(9.20%)>OFX(7.06%)>EMB(3.68%)>KM(2.15%).Conclusion It is important to solve the problem of treatment of elderly patients with tuberculosis and publish the guideline for them.
作者
王彦富
綦峥
张铁林
刘畅
李洪海
闫兴录
WANG Yan-fu;QI Zheng;ZHANG Tie-lin;LIU Chang;LI Hong-hai;YAN Xing-lu(Heilongjiang Provincial Center for Disease Control and Prevention,Harbin,Heilongjiang 150030,China;Harbin University of Commerce;First Affiliated Hospital of Harbin Medical University)
出处
《中国公共卫生管理》
2020年第2期234-238,共5页
Chinese Journal of Public Health Management
基金
黑龙江省卫生健康委员会科技计划(2019-181)。
关键词
老年组
肺结核
分布特征
耐药性
elderly group
tuberculosis
distribution characters
drug resistance
