摘要
生物素是一种水溶性维生素,在人体中作为一种重要的羧酸酶辅酶起作用,近年来受到化学家和生物学家的广泛青睐。此外,其在各种生理和病理过程中表现出低毒性,可以被设计成具有靶向选择性的药物载体,能将抗癌药物有效地传递给肿瘤细胞。如今含生物素的小分子已发展成一类具有显著应用价值的生物功能分子。该类化合物具有合成简便、易功能化和特异性强等优点。本文综述了生物素及其衍生物在生物传感、药物释放和其他领域的研究进展,并对其发展趋势做出了展望。
Biotin is a water-soluble vitamin and serves as a coenzyme for carboxylases in human body. It is widely favored by chemists and biologists in recent years. In addition, it exhibits low toxicity in various physiological and pathological processes, and can be designed as a selectivity targeting drug carriers, which can efficiently deliver therapeutic drugs to cells. Nowadays, small molecules containing biotin have developed into a class of biofunctional molecules of high utility value. These compounds have the advantages of simple synthesis, easy functionalization, and high specificity. In this paper, the progress of biotin and its derivatives in biosensors, drug release and other fields are systematically reviewed, and the prospects for their development are presented.
作者
张继东
刘阿晨
陈娇
袁光辉
金华峰
Jidong Zhang;Achen Liu;Jiao Chen;Guanghui Yuan;Huafeng Jin(Department of Chemistry and Chemical Engineering,Research Centre of New Materials,Quality Supervision and Inspection Centre of Se-enriched Food of Shaanxi Province,Ankang Univerisity,Ankang 725000,China;Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education,College ofChemistry&Materials Science,Northwest University,Xi’an 710127,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2020年第5期594-603,共10页
Progress in Chemistry
基金
陕西省科技厅重点项目(No.2018PT-31)
陕西省科技厅青年基金项目(No.2019JQ-504)
陕西省自然科学基金项目(No.2019JM-229)
安康学院博士科研启动基金(No.2018AYQDZR06)
农业部富硒产品开发国家地方联合工程实验室开放课题资助项目(Se-2018B02)资助。
关键词
生物素
荧光探针
生物成像
药物释放
biotin
fluorescent probe
biological imaging
drug delivery
