摘要
目的:研究并探讨泮托拉唑治疗脑出血后应激性溃疡的临床疗效。方法:选取收治的100例脑出血后应激性溃疡患者,对其进行前瞻性研究,按照计算机随机数字分组法,这100例脑出血后应激性溃疡患者被随机分为两组(对照组50例,观察组50例),入组对象均接受脑出血常规治疗,在此基础上,对照组患者给予雷尼替丁,观察组患者给予泮托拉唑,治疗7 d后,两组患者在临床疗效、止血时间、住院时间、不良反应发生率、生存质量评分、神经功能缺损评分、日常生活能力评分方面进行比较。结果:观察组的临床总有效率为96%,对照组为82%,观察组总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组的止血时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组、对照组的不良反应发生率分别为6%、2%,比较差异无统计学意义(P>0.05);两组患者治疗后的神经功能缺损评分均较治疗前显著降低(P<0.05),其生存质量评分、日常生活能力评分显著提高(P<0.05),而在治疗后,观察组的生存质量评分、神经功能缺损评分、日常生活能力评分均优于对照组,差异有统计学意义(P<0.05)。结论:采用泮托拉唑对脑出血后应激性溃疡患者进行治疗,不仅具有显著的疗效和安全性,还可起到加快病情控制、提高生存质量、改善神经功能和日常生活能力等多重作用。
Objective To study and explore the clinical effect of stress ulcer pantoprazole in the treatment of cerebral hemorrhage.Method 100 cases of cerebral hemorrhage patients with stress ulcer were selected,the prospective study was conducted,according to the digital computer random grouping method,100 cases after cerebral hemorrhage patients with stress ulcer were randomly divided into 2 groups(50 cases in the control group,the observation group of 50 cases),the subjects received conventional treatment of cerebral hemorrhage,on this basis,the control group were treated with ranitidine,the patients in the observation group were given pantoprazole,7 days after treatment,two groups of patients with clinical curative effect,hemostasis time,hospitalization time,the incidence of adverse reactions,quality of life score,neurological deficit score,ADL score.Results The clinical observation group,the total effective rate was 96%,the control group was 82%,the total efficiency of the observation group was significantly higher than the control group(P<0.05);the observation group hemostasis time,hospitalization time was shorter than the control group(P<0.05);the observation group,the control group adverse reaction rate were 6%,2%,respectively,no statistical differences(P>0.05);the two groups of patients after treatment of neurological deficit scores were significantly lower than before treatment(P<0.05),the quality of life score,ADL score increased significantly(P<0.05),and after treatment,observation group survival quality score,neurological deficit score,ADL score were better than the control group(P<0.05).Conclusion Using pantoprazole for treating patients with stress ulcer after cerebral hemorrhage,not only has significant efficacy and safety,but also can play to accelerate the disease control,improve the quality of life,improve neurological function and daily life Capacity and other multiple functions.
作者
晏喻婷
陈焱彬
YAN Yu-ting;CHEN Yan-bian(Department of spleen and stomach diseases,Chongqing Beibei Hospital of traditional Chinese Medicine,Chongqing 400700,China;The First Department of encephalopathy,Chongqing Beibei Hospital of traditional Chinese Medicine,Chongqing 400700,China)
出处
《吉林医学》
CAS
2020年第7期1582-1585,共4页
Jilin Medical Journal
关键词
脑出血
应激性溃疡
泮托拉唑
Cerebral hemorrhage
Stress ulcer
Pantoprazole
