摘要
目的探究血小板输注次数对弥散性血管内凝血(DIC)患者抗体筛查阳性率及输注效果的影响。方法选择2017年4月~2019年4月于我院接受治疗的92例DIC患者为研究对象,另外选择我院同期无输血史的择期行外科手术的79例患者为对照组,再将研究组患者根据血小板输注次数分为三个亚组:A组(≤3次,32例)、B组(4~8次,39例),C组(>8次,21例)。比较研究组和对照组及研究组三个亚组患者血小板抗体阳性率的差异,记录三个亚组患者输注血小板后血小板增高指数(CCI)值、输注效果差异,比较血小板抗体阳性、阴性患者输注效果及不同抗体阳性患者输注效果差异,分析血小板输注次数与血小板抗体阳性率、CCI值的相关性。结果研究组患者血小板抗体阳性率高于对照组(P<0.05);三个亚组血小板抗体阳性率与输注血小板后CCI值由高到低均依次为C组、B组、A组,C组患者PTR率高于A组、B组(P<0.05);血小板抗体阳性患者PTR率高于血小板抗体阴性患者(P<0.05);血小板不同抗体阳性患者PTR率差异无统计学意义(P>0.05);DIC患者血小板输注次数与血小板抗体阳性率呈正相关(r=0.348,P<0.05),与患者输注后CCI值呈负相关(r=-0.241,P<0.05)。结论随着血小板输注次数的增加,血小板抗体筛查阳性率也随之增加,而CCI值降低,且血小板输注次数与输注效果有一定关系。
Objective To explore the influence of platelet transfusion frequency on antibody screening positive rate and transfusion effects in patients with disseminated intravascular coagulation(DIC).Methods A total of 92 patients with DIC who were treated in our hospital from Apr 2017 to Apr 2019 were selected as the research subjects.In addition,79 patients who had undergone elective surgery without a history of blood transfusion in our hospital during the same period were selected as control group.92 patients were divided into three subgroups according to the platelet transfusion frequency,including group A(≤3 times,32 cases),group B(4~8 times,39 cases)and group C(>8 times,21 cases).The differences in platelet antibody positive rate were compared between study group and control group and among A,B and C subgroups of study group,and the corrected count increment(CCI)value and transfusion effects after platelet transfusion were compared among 3 subgroups.The transfusion effect of platelet antibody positive and negative patients and transfusion effect of different positive antibodies were compared,and the correlation between platelet transfusion frequency and platelet antibody positive rate and CCI value was analyzed.Results The positive rate of platelet antibody in study group was higher than that in control group(P<0.05).The positive rate of platelet antibody and CCI value after platelet transfusion in 3 subgroups from high to low were group C,group B,group A(P<0.05).The PTR rate in group C was higher than that in group A and group B(P<0.05).The PTR rate of platelet antibody positive patients was higher than that of platelet antibody negative patients(P<0.05).There was no significant difference in the PTR rate among patients with different positive platelet antibodies(P>0.05).The platelet transfusion frequency was positively correlated with platelet antibody positive rate in DIC patients(r=0.348,P<0.05),and which was negatively correlated with the CCI value after platelet transfusion(r=-0.241,P<0.05).Conclusion With th
作者
王中正
Wang Zhongzheng(The First People's Hospital of Zhengzhou,Zhengzhou 450000)
出处
《中国现代医药杂志》
2020年第6期35-38,共4页
Modern Medicine Journal of China
关键词
血小板输注
弥散性血管内凝血
抗体
输注效果
筛查
Platelet transfusion
Disseminated intravascular coagulation
Antibody
Transfusion effects
Screening
