摘要
目的探讨噻托溴铵联合布地奈德雾化吸入治疗慢性阻塞性肺疾病的临床效果。方法选取2018年10月~2019年10月于我院门诊接受治疗的96例慢性阻塞性肺疾病患者作为研究对象,依据双盲法将其分为观察组和对照组,每组各48例。所有患者均接受基础治疗,对照组患者加用噻托溴铵治疗,观察组患者在对照组基础上联合布地奈德雾化吸入治疗。对比分析两组患者的临床疗效及不良反应发生情况,研究两组患者治疗前后的肺功能、氧合指数及血气指标的变化情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗2周后,观察组患者的用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1与FVC比值(FEV1/FVC)、氧合指数、动脉血氧分压(PaO2)水平均高于对照组,动脉血二氧化碳分压(PaCO2)水平低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论使用噻托溴铵联合布地奈德雾化吸入治疗慢性阻塞性肺疾病可达较好的临床效果,能显著改善患者的低氧状态及肺功能,且具有较高的安全性。
Objective To investigate the clinical effect of Tiotropium Bromide combined with Budesonide atomization inhalation in the treatment of chronic obstructive pulmonary disease.Methods A total of 96 patients with chronic obstructive pulmonary disease who were treated in outpatient clinic of our hospital from October 2018 to October 2019 were selected as subjects.They were divided into observation group and control group based on double-blind method,48 cases in each group.All patients received basic treatment,the control group was treated with Tiotropium Bromide,and the observation group was combined with Budesonide atomization inhalation therapy based on the control group.The clinical efficacy and adverse reactions of the two groups were compared and analyzed.The changes of lung function,oxygenation index and blood gas index before and after treatment in the two groups were studied.Results The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After 2 weeks of treatment,the levels of forced expiratory volume(FVC),forced expiratory volume in the first second(FEV1),ratio of FEV1 to FVC(FEV1/FVC),oxygenation index,and arterial partial oxygen pressure(PaO2)in the observation group were higher than those in the control group,and partial pressure of carbon dioxide in artery(PaCO2)level was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Tiotropium Bromide combined with Budesonide atomization inhalatio can achieve good clinical efficacy in treating chronic obstructive pulmonary disease,which can significantly improve the hypoxic state and lung function of patients,and has high safety.
作者
杜月君
DU Yue-jun(Department of Respiratory and Critical Care Medicine,Chengdu Second People′s Hospital,Sichuan Province,Chengdu 610015,China)
出处
《中国当代医药》
2020年第17期65-68,共4页
China Modern Medicine
关键词
慢性阻塞性肺疾病
噻托溴铵
布地奈德
氧合指数
肺功能
Chronic obstructive pulmonary disease
Tiotropium Bromide
Budesonide
Oxygenation index
Pulmonary function
