摘要
可溶微针是一种极具潜力的新型透皮给药技术,它具有药物递送可控性、可调节性以及自我给药的便捷性等特点,在生物医学领域具有广阔的应用前景。综述微针技术的研究进展,包括微针分类、常用材料和制备方法,重点介绍了可溶微针在小分子、多肽、蛋白和核酸等药物递送领域的研究进展,系统讨论了可溶微针在生物医学领域的发展前景,以期为更精准智能的可溶微针经皮递药系统的研发提供参考。
Dissolving microneedles(DMNs)are promising transdermal drug delivery systems due to their unique properties,including controlled drug delivery,tunability,and ease of self-administration for patients.In this review,great efforts were made to summarize the advances of microneedles including classification,materials for microneedles,and the latest fabrication methods.Importantly,a variety of representative biomedical applications of DMNs such as small molecules,peptides,proteins,and nucleic acids delivery were highlighted.At last,conclusion and future perspective for the development of advanced DMNs in biomedical fields were systematically discussed.Taken together,as an emerging tool,DMNs have shown profound promise for biomedical applications,providing reference for the research and development of more accurate and intelligent dissolving microneedles in transdermal drug delivery system.
作者
陈明龙
杨丹
孙颖
权桂兰
吴传斌
潘昕
CHEN Minglong;YANG Dan;SUN Ying;QUAN Guilan;WU Chuanbin;PAN Xin(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;College of Pharmacy,Jinan University,Guangzhou,510632,China)
出处
《药学进展》
CAS
2020年第5期324-331,共8页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81803466)
广东省中医药局面上项目(No.20191057)。
关键词
可溶微针
经皮药物递送
生物医药
dissolving microneedle
transdermal drug delivery
biomedicine
