摘要
目的系统评价PD-1和PD-L1的表达对胃癌患者预后的影响。方法对PubMed、Web of Science、Cochrane Library、中国生物医学数据库(CBM)、Embase、中国知网(CNKI)等数据库进行文献检索。纳入研究为PD-1/PD-L1表达与胃癌患者预后关系的队列研究。采用RevMan 5.3软件对总生存期(OS)进行Meta分析。结果共纳入10项(3 093例胃癌患者)符合条件的队列研究。单因素和多因素分析显示,PD-1和PD-L1的表达与胃癌患者预后无明显相关性,PD-1的高表达与淋巴结转移(N^+)有显著相关性,PD-L1的高表达与胃癌晚期(Ⅲ~Ⅳ)有显著相关性。结论 PD-1和PD-L1表达与胃癌患者预后无明显相关性。
Objective To systematically evaluate the effect of PD-1 and PD-L1 expression on the prognosis of gastric cancer patients.Methods A comprehensive literature review was conducted in PubMed,Web of Science,Cochrane Library,China Biology Medicine Database(CBM),Embase and China National Knowledge Infrastructure(CNKI)databases.The cohort studies about the association of PD-1 and PD-L1 expression with the prognosis of GC patients were identified and included.RevMan 5.3 software was used to perform the meta-analysis for overall survival(OS).Results We included 10 eligible cohort studies comprising 3093 patients with GC.Univariate and multivariate analyses indicated no significant correlation of PD-1 and PD-L1 expression with the prognosis of GC patients,however,high PD-L1 and PD-1 expression were significantly correlated with advanced stages(Ⅲ-Ⅳ)of GC and lymph node metastasis(N^+),respectively.Conclusion There is no significant correlation of PD-1 and PD-L1 expression with the prognosis of gastric cancer patients.
作者
王玉丰
姚南
王军
闵光涛
WANG Yufeng;YAO Nan;WANG Jun;MIN Guangtao(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《肿瘤防治研究》
CAS
CSCD
2020年第5期346-352,共7页
Cancer Research on Prevention and Treatment
基金
兰州大学第一医院院内基金(ldyyyn2018-57)。
