摘要
目的:研究胺碘酮对急性心肌梗死(AMI)合并心房颤动(AF)患者的临床疗效和AF控制效果。方法:本院2015年1月~2019年6月间收治的120例AMI+AF患者被随机均分为毛花苷丙组和胺碘酮组,两组均接受常规治疗。观察比较两组治疗后6h、12h、24h、48h的AF控制率,随访30d时的窦性心律维持率,治疗72h后的临床疗效、心率、P-R间期、QTc间期和LVEF,以及治疗期间的不良反应发生率。结果:与毛花苷丙组比较,胺碘酮组治疗后6h、12h、24h、48h时AF控制率(10.00%比30.00%;16.67%比53.33%;36.67%比73.33%;56.67%比90.00%)均显著升高,随访30d时的窦性心律维持率(48.33%比86.67%)亦显著升高,P均<0.01。治疗72h后,与毛花苷丙组比较,胺碘酮组心率[(82.81±10.65)次/min比(75.69±9.71)次/min]显著降低,P-R间期[(142.71±15.32)ms比(149.18±16.13)ms]、QTc间期[(402.08±17.41)ms比(418.25±19.65)ms]和LVEF[(45.12±6.28)%比(51.96±7.14)%]均显著升高,P<0.05或<0.01。治疗期间,胺碘酮组的不良反应发生率显著低于毛花苷丙组(6.67%比36.67%),P=0.001。结论:胺碘酮能够显著提高急性心肌梗死合并房颤患者的房颤控制率与临床疗效,并可显著提高窦性心律维持率,且用药安全性高,值得推广。
Objective:To study therapeutic effect of amiodarone on patients with acute myocardial infarction(AMI)complicated atrial fibrillation(AF)and its control effect on AF.Methods:A total of 120 AMI+AF patients treated in our hospital from Jan 2015 to Jun 2019 were randomly and equally divided into lanatoside C group and amiodarone group,both groups received routine treatmental all.AF control rate on 6h,12h,24h and 48h after treatment,sinus rhythm maintenance rate after 30d follow-up,therapeutic effect,heart rate,P-R interval,QTc interval and LVEF on 72h after treatment,and incidence rate of adverse reactions during treatment were observed and compared between two groups.Results:Compared with lanatoside C group,there were significant rise in AF control rate on 6h,12h,24h and 48h after treatment(10.00%vs.30.00%;16.67%vs.53.33%;36.67%vs.73.33%;56.67%vs.90.00%)and sinus rhythm maintenance rate after 30d follow-up(48.33%vs.86.67%)in amiodarone group,P<0.01 all.Compared with lanatoside C group on 72h after treatment,there was significant reduction in heart rate[(82.81±10.65)beats/min vs.(75.69±9.71)beats/min],and significant rise in P-R interval[(142.71±15.32)ms vs.(149.18±16.13)ms],QTc interval[(402.08±17.41)ms vs.(418.25±19.65)ms]and LVEF[(45.12±6.28)%vs.(51.96±7.14)%]in amiodarone group,P<0.05 or<0.01.During treatment,incidence rate of adverse reactions in amiodarone group was significantly lower than that of lanatoside C group(6.67%vs.36.67%),P=0.001.Conclusion:Amiodarone can significantly improve AF control rate,therapeutic effect,and sinus rhythm maintenance rate in AMI+AF patients with high safety,which is worth extending.
作者
邓成英
罗琴
宋玲
吴煜
DENG Cheng-ying;LUO Qin;SONG Ling;WU Yu(Department of Cardiology,Shizhong District People's Hospital of Leshan City,Leshan,Sichuan,614000,China)
出处
《心血管康复医学杂志》
CAS
2020年第3期361-365,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗死
心房颤动
胺碘酮
Myocardial infarction
Atrial fibrillation
Amiodarone
