摘要
目的:观察中药结合西药治疗子宫内膜癌术后化疗患者的临床疗效及其对生活质量的影响。方法:采用前瞻性分析,收集2015年1月-2019年1月期间本院收治的子宫内膜癌患者110例,各组55例;观察组和对照组患者入院后均给予手术治疗和TP方案化疗。观察组在此基础上给予清热解毒方、黄芪注射液治疗。观察治疗前后2组血清HE4、CA125变化和免疫功能指标IgG、IgA、CD4^+、NK细胞变化。观察2组治疗前后中医证候积分。比较2组毒副反应情况。结果:①治疗后2组患者血清HE4、CA125水平均显著降低,其中观察组低于对照组,差异有统计学意义(P<0.05)。②治疗后2组患者IgG、IgA均显著降低,CD4^+、NK均显著升高,其中观察组IgG、IgA较对照组低,CD4^+、NK较对照组高,差异有统计学意义(P<0.05)。③治疗后2组中医证候各项分值均降低且观察组低于对照组,差异有统计学意义(P<0.05)。④观察组Ⅱ、Ⅲ度胃肠道反应率为9.09%,Ⅱ、Ⅲ度骨髓抑制发生率为14.54%,Ⅱ、Ⅲ度肝功能损伤发生率为18.18%均低于对照组(20.00%、34.55%、32.72%),差异有统计学意义(P<0.05)。结论:在常规手术和化疗基础上给予子宫内膜癌术后患者清热解毒方、黄芪注射液,能有效抑制恶性肿瘤细胞进展,改善患者机体免疫功能和中医证候积分,利于预后。
Objective:To observe the clinical effect of Chinese medicine combined with western medicine for patients undergoing postoperative chemotherapy for endometrial carcinoma and its effect on the quality of life. Methods:A total of 110 cases of patients with endometrial carcinoma who were admitted and treated in our hospital during January,2015 to January, 2019 were collected via prospective analysis, 55 cases in each group. Both groups, including the observation group and the control group, were given surgical treatment and TP regimen chemotherapy after hospitalization, and the observation group was additionally given Qingre Jiedu prescription and astragalus injection. The changes in the levels of HE4 and CA125 in serum and the indexes of immune function including IgG,IgA,CD4^+ and NK cells in the two groups were observed before and after treatment. Chinese medicine syndrome scores in the two groups were observed before and after treatment. The occurrence of toxic side effects in the two groups was compared. Results:①After treatment,the levels of HE4 and CA125 in serum in the two groups were significantly decreased,and the above two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). ②After treatment,the indexes of IgG and IgA in the two groups were significantly decreased, and the indexes of CD4^+ and NK were significantly increased;the indexes of IgG and IgA in the observation group were lower than those in the control group,and the indexes of CD4+and NK were higher than those in the control group;differences were significant(P<0.05). ③ After treatment, each Chinese medicine syndrome score in the two groups was decreased,and the score in the observation group was lower than that in the control group(P<0.05). ④In the observation group,the reaction rate of gastrointestinal tract of Ⅱ and Ⅲ degree in the observation group was 9.09%,the incidence of inhibiting bone marrow of Ⅱ and Ⅲ degree 14.54%,and the incidence of liver dysfunction of Ⅱ
作者
娄雪玲
刘灵
封全灵
张林东
刘萍萍
王智霆
LOU Xueling;LIU Ling;FENG Quanling;ZHANG Lindong;LIU Pingping;WANG Zhiting
出处
《新中医》
CAS
2020年第10期99-101,共3页
New Chinese Medicine
基金
河南省医学学术技术带头人出国研修计划项目(2017041)。
关键词
子宫内膜癌
化疗
激素治疗
清热解毒方
黄芪注射液
Endometrial carcinoma
Chemotherapy
Hormone therapy
Qingre Jiedu prescription
Astragalus injection
