摘要
循环肿瘤细胞被认为是肿瘤转移的一个重要因素,其精确检测对监控患者病情、治疗效果以及预测预后具有重要的临床指导意义。然而,由于在外周血中的循环肿瘤细胞个数极少,对它的检测要求使用高特异性、高灵敏度的快速检测技术。近些年纳米技术的发展为循环肿瘤细胞的检测提供了新的机遇。文章综述了近年来循环肿瘤细胞分离与检测技术的研究进展,重点介绍了纳米材料、微流控技术在循环肿瘤细胞捕获中发挥的重要性。
Circulating tumor cells(CTCs)have long been considered as one of important causes of cancer metastasis.Precise monitoring of CTCs is crucial for early disease,monitoring the therapeutic outcomes and evaluating cancer prognosis.The most important technical challenges with regard to CTC detection arise from not only the low CTC concentration in bone marrow or blood but also the presence of other cellular contaminants.Therefore,CTC detection requires rapid,extremely sensitive and specific analytical methods.Recently,nanotechnology has emerged as a solution to detect CTCs.This study reviews the recent progress of detection and isolation of CTCs,especially the application of nanostructured materials and microfluidic systems in capture of CTCs.
作者
刘洋
刘绍琴
LIU Yang;LIU Shaoqin(Interdisciplinary Science Research Center,Harbin Institute of Technology,Harbin 150090,China)
出处
《自然杂志》
2020年第3期201-209,共9页
Chinese Journal of Nature
关键词
循环肿瘤细胞
纳米材料
微流控
特异性捕获
circulating tumor cell
nanostructured material
microfluidic
specific capture
