摘要
信号传导与转录活化因子3(STAT3)是具有转录活性的癌基因,广泛参与各项细胞生理及病理学过程,其中包括恶性肿瘤的发生、侵袭转移、免疫调节等。研究显示,STAT3异常激活与多种上皮系统来源的恶性肿瘤,如头颈部鳞状细胞癌、结直肠癌、脑胶质瘤、肝细胞癌及肺癌等的发生与预后不良密切相关。此外,通过RNA干扰和小分子抑制剂降低肿瘤细胞中STAT3的表达或活化也能有效抑制肿瘤生长和免疫逃逸。本文在结合国内外文献报道和本课题组研究工作进展的基础上,就STAT3信号通路在头颈部鳞癌中的研究进展进行综述。
Signal transduction and activator of transcription 3(STAT3)is an oncogene with transcription activity.STAT3 is widely involved in multiple cellular physiological or pathological processes including cancer oncogenesis,metastasis and immunology modulation.The abnormal activation of STAT3 is associated with the oncogenesis or poor prognosis of multiple epithelium original malignant tumors(head and neck squamous cell carcinoma,colorectal cancers,glioma,hepatocellular carcinoma and lung cancer).Additionally,RNA interference or small molecular inhibitor treatment can inhibit the expression or activation of STAT3 in tumor cells and immune escape.Based on the domestic and foreign literature reports and the progress of our own research,this review article provides a brief summary of the latest progress on STAT3 signaling pathway in head and neck cancer research.
作者
周旋
任玉
乔宇
ZHOU Xuan;REN Yu;QIAO Yu(Department of Maxillofacial and Otorhinolaryngology Oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China;Department of Genetics,Basic Medical College,Tianjin Medical University)
出处
《天津医药》
CAS
北大核心
2020年第6期563-567,共5页
Tianjin Medical Journal
基金
国家自然科学基金资助项目(81872206、81872495)。
关键词
STAT3转录因子
头颈部肿瘤
癌
鳞状细胞
癌基因
STAT3 transcription factor
head and neck neoplasms
carcinoma
squamous cell
oncogenes
