摘要
目的观察加巴喷丁联合度洛西汀治疗带状疱疹后神经痛(Postherpetic neuralgia,PHN)的临床效果,为临床提供一种可行的治疗方法。方法将63例PHN患者随机分为治疗组31例和对照组32例。对照组予单药服用加巴喷丁,最终计量为1800 mg/d;治疗组在服用相同计量加巴喷丁的基础上联合服用度洛西汀60 mg/d。两组均治疗4周,观察比较两组患者治疗前和治疗后第1、2、4周的视觉模拟疼痛评分(VAS)、睡眠质量评分(QS),并记录不良反应发生率。结果两组患者治疗后各时间点的疼痛评分均较治疗前下降,睡眠质量明显改善(P<0.05)。治疗组的VAS评分、QS评分下降幅度明显优于对照组,差异均有统计学意义(P<0.05)。治疗组的治愈率及有效率(48.39%和87.1)均高于对照组(31.25%和62.5%),差异均有统计学意义(P>0.05)。两组患者治疗过程中均未出现严重的药物不良反应。结论加巴喷丁联合度洛西汀治疗PHN的疗效确切,临床效果优于单独口服加巴喷丁,且无明显不良反应。
Objective To observe the clinical effect of gabapentin combined with duloxetine in the treatment of post herpetic neuralgia,so as to provide a feasible treatment for the treatment of such pain.Methods 63 PHN patients were randomly divided into treatment group(31 cases)and control group(32 cases).The final dose of gabapentin was 1800 mg/D in the control group,and duloxetine was 60 mg/D in the treatment group on the basis of the same dose of gabapentin.The course of treatment was 4 weeks.The visual analogue pain score(VAS)and sleep quality score(QS)were recorded before and 1,2,4 weeks after treatment,and the adverse reactions were recorded.Results during the 4-week observation period,the pain score of the two groups decreased with time at each time point after treatment compared with that before treatment.Sleep time increased(P<0.05).The VAS score and QS score of the treatment group decreased more than that of the control group,and the sleep time increased more than that of the control group(P<0.05).The cure rate and effective rate of the treatment group(48.39%and 87.1)were higher than that of the control group(31.25%and 62.5%)(P<0.05).There was no serious adverse drug reaction in the two groups.Conclusion The therapeutic effect of gabapentin combined with duloxetine on PHN is better than that of gabapentin alone,and there is no obvious adverse reaction.
作者
林自恒
黄礼传
周杜娟
LIN Zi-heng;HUANG Li-chuan;ZHOU Du-juan(Fuzhou Institute of Neuropsychiatry,Fuzhou,Fujian,350008,China)
出处
《蛇志》
2020年第2期173-174,191,共3页
Journal of Snake
