摘要
目的:探讨康莱特注射液对晚期肺癌化疗患者免疫功能的影响。方法:选择2016年8月-2018年6月在笔者所在医院接受化疗的80例肺癌患者的临床资料进行回顾性分析,依据治疗方式不同将其分为对照组和观察组,每组40例。对照组采用常规GP方案化疗,观察组在对照组基础上给予康莱特注射液。比较两组治疗效果。结果:化疗后,两组CD3^+、CD4^+、CD4^+/CD8^+水平均较化疗前降低,化疗后观察组的CD3^+、CD4^+、CD4^+/CD8^+水平均高于对照组,差异有统计学意义(t=-3.021、-3.511、-6.394,P<0.05)。化疗后,两组CRP、TNF-α、IL-6水平均较化疗前降低,且观察组均低于对照组,差异有统计学意义(t=6.551、21.177、20.139,P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(χ^2=4.528,P<0.05)。结论:对晚期肺癌化疗患者使用康莱特注射液,降低对免疫功能的影响,降低炎性反应程度,安全性良好。
Objective:To explore the effect of Kanglaite Injection on immune function in patients with advanced lung cancer undergoing chemotherapy.Method:Clinical data of 80 patients with lung cancer who underwent chemotherapy in our hospital from August 2016 and June 2018 were selected for retrospective analysis.According to different treatment methods,they were divided into the control group and the observation group,with 40 cases in each group.The control group received conventional GP chemotherapy,and the observation group was given Kanglaite Injection on the basis of the control group.The treatment effects of the two groups were compared.Result:After chemotherapy,the levels of CD3^+,CD4^+,CD4^+/CD8^+ in both groups were lower than those before chemotherapy,and the levels of CD3^+,CD4^+,CD4^+/CD8^+ in the observation group were higher than those in the control group after chemotherapy,the differences were statistically significant (t=-3.021,-3.511,-6.394,P<0.05).After chemotherapy,the levels of CRP,TNF-α and IL-6 in both groups were lower than those before chemotherapy,and the observation group were lower than those in the control group,the differences were statistically significant (t=6.551,21.177,20.139,P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (χ^2=4.528,P<0.05).Conclusion:The use of Kanglaite Injection in advanced lung cancer patients undergoing chemotherapy can reduce the impact on immune function,reduce the degree of inflammatory response,and is safe.
作者
李正国
曾多
席彩霞
陶文学
LI Zhengguo;ZENG Duo;XI Caixia;TAO Wenxue(Wuwei Cancer Hospital of Gansu,Wuwei 733000,China;不详)
出处
《中外医学研究》
2020年第14期42-44,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
康莱特注射液
晚期肺癌
化疗
免疫功能
Kanglaite Injection
Advanced lung cancer
Chemotherapy
Immune function
