摘要
为探讨高剂量放疗联合化疗对拒绝手术治疗的直肠癌患者疗效及并发症的影响,将98例直肠癌患者随机分为对照组和观察组,每组49例。对照组患者采用单纯化疗方案治疗,观察组患者在对照组治疗的基础上采用高剂量放疗方案治疗,观察比较2组患者临床疗效,生存率和并发症发生情况。结果显示,观察组总有效率为77.55%,对照组为55.10%,观察组明显高于对照组(P<0.05);观察组无进展生存率低于对照组(P<0.05),总生存率高于对照组(P<0.05);观察组腹泻、血小板减少及白细胞下降发生率低于对照组(P<0.05)。结果表明,对于拒绝手术治疗的直肠癌患者采用高剂量放疗联合化疗方案,可有效改善患者的临床症状,提高生存率。
This study was to investigate the influence of high-dose radiotherapy combined with chemotherapy on the effect and complication of the rectal cancer patients refusing surgery,randomly divided 98 cases into control group(49 cases,alone chemotherapy)and observation group(49 cases,the combination of high-dose radiotherapy and chemotherapy);then compared both groups’effect,survival rate,and complication incidence.As results,in total effective rate,in non-advanced survival rate,in total survial rate,and in complication incidence(diarrhea,thrombocytopenia,and leukopenia),observation group was respectively and significantly higher(77.55%vs 55.10%),lower,higher and lower than control group(all,P<0.05).Results show that above combination therapy is more effective,can improve clinical symptoms,enhance survival rate.
作者
郭君兰
王艳霞
王丽华
胡彦伟
GUO Jun-lan;WANG Yan-xia;WANG Li-hua;HU Yan-wei(The Oncology Hospital of Anyang City,Henan 455000)
出处
《中国肛肠病杂志》
2020年第3期14-16,共3页
Chinese Journal of Coloproctology
关键词
直肠癌
高剂量放疗
化疗
疗效
并发症
Rectal cancer
High-dose radiotherapy
Chemotherapy
Effect
Comlication
