摘要
炎症性肠病(IBD)是一组病因不明且反复发作的肠道慢性炎症性疾病,既往已有的证据表明宿主不恰当的免疫反应与IBD的发生密切相关。越来越多的研究表明髓样细胞触发受体(TREM)-1可以调节多种信号通路,参与IBD的发生和发展,本文综述TREM-1在IBD中的研究进展,进一步阐明IBD的发生机制。
Inflammatory bowel disease(IBD)is a group of recurrent chronic intestinal inflammatory diseases.The precise etiology of IBD remains unclear,but the inappropriate immune response is considered the leading cause of IBD.More and more studies indicated that triggering receptor expressed on myeloid cells(TREM)-1 have regulated multiple signaling pathways.This review will focus specifically on recent insights into the role of TREM-1 proteins in IBD development,and discuss opportunities for novel treatment approaches.
作者
耿丽
张目涵
王许平
王丹丹
杨贝贝
高闯
杜晓博
冯百岁
Geng Li;Zhang Muhan;Wang Xuping;Wang Dandan;Yang Beibei;Gao Chuang;Du Xiaobo;Feng Baisui(Department of Gastroenterology,The Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014,China)
出处
《中华炎性肠病杂志（中英文）》
2020年第2期154-157,共4页
Chinese Journal of Inflammatory Bowel Diseases
基金
国家自然科学基金资助项目(81070288、81270452)
河南省自然科学基金项目(162300410268)
河南省医学科技攻关计划项目(201502015)。
关键词
炎症性肠病
髓样细胞触发受体1
TOLL样受体
可溶性髓样细胞触发受体1
Inflammatory bowel disease
Triggering receptor expressed on myeloid cells-1
Toll-like receptor
Soluble triggering receptor expressed on myeloid cells-1
