摘要
以7-羟基四氢喹喔啉-6-甲醛为基础,设计合成了一种新型酰腙类荧光探针L,探针在DMSO/Tris(V:V=7:3)溶液中能够高选择性识别Al3+.向该探针中加入Al3+后由无荧光变为紫红色荧光,最大发射波长为640 nm,达到近红外范围,并且具有较大的斯托克斯位移(170 nm),检测限为0.521μmol/L,pH适用范围为5~9.此外,探针L可在实际水样中对Al3+进行检测,还可在MCF-7细胞中对Al3+进行荧光成像.
A novel acylhydrazone derivative(i.e.fluorescence probe L)was designed and synthesized based on 7-hydroxy-tetrahydroquinoxaline-6-formaldehyde.Probe L can recognize for Al3+with highly selectivity in DMSO/Tris(V:V=7:3)solution.When Al3+is added into the solution of L,the fluorescence color of solution changes from non-fluorescence to purple red fluorescence,and the maximum emission wavelength of L is 640 nm within range of the near-infrared.Probe L possesses a large Stokes shift(170 nm)and the detection limit of L is 0.521μmol/L.In addition,L can detect Al3+in the real water samples and imaging for Al3+in MCF-7 cells.
作者
钟克利
周璐璐
邓隆隆
汤立军
高雪
刘秀英
燕小梅
Zhong Keli;Zhou Lulu;Deng Longlong;Tang Lijun;Gao Xue;Liu Xiuying;Yan Xiaomei(College of Chemistry and Chemical Engineering,Bohai University,Jinzhou,Liaoning 121013;National&Local Joint Engineering Research Center of Storage,Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products,College of Food Science and Technology,Bohai University,Jinzhou,Liaoning 121013;College of Laboratory Medicine,Dalian Medical University,Dalian 116044)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第5期1251-1256,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21878023,U1608222)
辽宁省自然科学基金(No.20180551195)
辽宁省教育厅科学研究基金(No.LJ2019005)
辽宁省高等学校基本科研项目(No.LQ2017048)
辽宁省特聘教授支持计划资助项目.
