摘要
N-芳基磺酰胺骨架广泛存在于具有生物活性的分子中,在医药领域有十分重要的应用.因此研究N-芳基磺酰胺类化合物的合成方法受到了人们的广泛关注.近年来过渡金属催化的卤代芳烃、芳基硼酸和CAr—H键的磺酰胺化反应得到了快速发展,为N-芳基磺酰胺类化合物的合成提供了高效、绿色的方法.按照芳基源、过渡金属催化剂、配体和磺酰胺化试剂进行分类,综述了过渡金属催化的芳环磺酰胺化反应的最新研究进展,并对此类反应的研究方向进行了展望.
The N-arylsulfonamide group is an important moiety in medicinal chemistry because of its presence in many useful molecules with potential bioactivities.As a result,the development of synthetic routes to N-arylsulfonamides has been actively investigated.In recent years,the transition metal-catalyzed sulfonamidations of aryl halides,arylboronic acids and CAr-H bonds have extensively investigated,providing more efficient and environmentally friendly procedures for the synthesis of N-arylsulfonamides.The recent progress in the transition metal-catalyzed sulfonamidation reactions is reviewed.The aromatic substrates,transition metal-catalysts,ligands,sulfonamidating reagents,mechanisms of the sulfonamidation reactions are mainly discussed.Finally,the future development of them is also prospected.
作者
欧阳班来
郑燕霞
夏克坚
徐小玲
王艺
Ouyang Banlai;Zheng Yanxia;Xia Kejian;Xu Xiaoling;Wang Yi(Department of Chemistry,Nanchang Normal University,Nanchang 330032)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第5期1188-1205,共18页
Chinese Journal of Organic Chemistry
基金
江西师范大学功能有机小分子教育部重点实验室开放课题(No.KLFS-KF-201721)
江西省教育厅科学技术研究(No.GJJ161235)资助项目.
