摘要
目的探讨年龄、体质指数(BMI)对胚胎发育时间动力学参数、胚胎发育潜能及临床妊娠结局的影响。方法回顾性分析2016年9月至2018年11月在郑州大学第一附属医院生殖医学中心行体外受精-胚胎移植(IVF-ET)的832例患者共6294枚胚胎的资料,根据年龄分为2组:<35岁组(655例、5076枚胚胎)、≥35岁组(177例、1218枚胚胎);根据BMI分为3组:低体重组(BMI<18.5 kg/m2,47例、355枚胚胎)、正常体重组(18.5~23.9 kg/m2,517例、3813枚胚胎)、超重组(BMI>23.9 kg/m2,268例、2126枚胚胎),比较各组胚胎发育时间动力学参数、胚胎发育潜能及临床妊娠结局。结果<35岁组患者的胚胎发育到3个细胞、4个细胞速度更快;两个年龄组患者囊胚形成率、优质囊胚形成率、妊娠率、种植率、分娩率、活产率、流产率差异均有统计学意义(均P<0.05)。低体重组、正常体重组、超重组患者的正常受精率、卵裂率、胚胎利用率、优质胚胎率、妊娠率、种植率、流产率、分娩率、活产率等差异均无统计学意义(均P>0.05)。结论年龄对部分胚胎发育时间动力学参数有影响,而BMI对其影响较小。
Objective To investigate the effects of age and body mass index(BMI)on embryo development time kinetic parameters,embryo development potential and clinical pregnancy outcomes.Methods A retrospective study was conducted to analyze the data of 6294 embryos from 832 patients who underwent in vitro fertilization and embryo transfer(IVF-ET)in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from September 2016 to November 2018.According to the age,they were divided into two groups:<35-year-old group(655 cases,5076 embryos),≥35-year-old group(177 cases,1218 embryos).According to the BMI,they were divided into three groups:low body mass group(BMI<18.5 kg/m^2,47 cases,355 embryos),normal body recombination(18.5-23.9 kg/m^2,517 cases,3813 embryos),hyperrecombination(BMI>23.9 kg/m^2,268 cases,2126 embryos).Embryo development time kinetic parameters,embryo development potential and clinical pregnancy outcomes in each group were compared.Results Embryo development to 3 cells,4 cells were faster in<35-year-old group than in≥35-year-old group.The blastocyst formation rate,high-quality blastocyst formation rate,pregnancy rate,implantation rate,delivery rate,live birth rate,and abortion rate were all statistically significant(all P<0.05).There were no significant differences in normal fertilization rate,cleavage rate,embryo utilization rate,high quality embryo rate,pregnancy rate,implantation rate,abortion rate,delivery rate,live birth rate between the three BMI groups(all P>0.05).Conclusions The age has an effect on the partial embryo development time kinetic parameters,but BMI has a little effect on it.
作者
金海霞
王赛赛
宋文妍
姚桂东
石森林
吴瞾婷
刘艳
祁琳
Jin Haixia;Wang Saisai;Song Wenyan;Yao Guidong;Shi Senlin;Wu Zhaoting;Liu Yan;Qi Lin(Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2020年第17期1326-1331,共6页
National Medical Journal of China
关键词
年龄
体质指数
胚胎移植
妊娠结局
Age
Body mass index
Embryo transfer
Pregnancy outcome
