摘要
目的分析拉米夫定联合干扰素治疗乙型肝炎病毒(HBV)感染的临床效果以及对患者自身免疫功能的影响。方法选择2018年2月至2019年5月入院接受治疗的80例乙型肝炎病毒感染病患为对象,使用数字表法为患者实施分组,对照组及观察组各40例。对照组采取常规疗法,观察组则增加使用拉米夫定以及干扰素,对比治疗效果以及两组患者治疗前后免疫功能。结果观察组治疗后HBeAg转阴率为20.0%、HBV-DNA转阴率为25.0%,均明显高于对照组(P<0.05)。比较治疗前两组患者的CD4+、CD4+/CD8+、CD8+等免疫功能指标,均显示差异无意义(P<0.05)。治疗后对比则均显示观察组优于对照组(P<0.05)。结论使用干扰素以及拉米夫定为乙型肝炎病毒感染病患实施治疗可显著提高该疾病的治疗效果,改善患者的免疫功能,应用价值较为显著。
Objective To analyze the clinical effect of lamivudine combined with interferon in the treatment of hepatitis B virus(HBV)infection and its influence on patients'autoimmune function.Methods 80 patients with hepatitis B virus infection admitted to hospital for treatment from February 2018 to May 2019 were selected as the subjects,and the patients were divided into two groups by digital table method,with 40 cases in the control group and 40 cases in the observation group.The control group received routine therapy,while the observation group received increased use of lamivudine and interferon.The therapeutic effects and immune functions of the two groups before and after treatment were compared.Results after treatment,the HBeAg negative conversion rate and HBV-DNA negative conversion rate in the observation group were 20.0%and 25.0%,respectively,which were significantly higher than those in the control group(P<0.05).The comparison of CD4+,CD4+/CD8+,CD8+and other immune function indexes between the two groups before treatment showed no significant difference(P<0.05).After treatment,the comparison showed that the observation group was superior to the control group(P<0.05).Conclusion The use of interferon and lamivudine for the treatment of hepatitis B virus infection patients can significantly improve the therapeutic effect of the disease,improve the immune function of patients,and has significant application value.
作者
宛月
WAN Yue(Department of Infection,Jinzhou City Center Hospital,Jinzhou 121000,China)
出处
《中国医药指南》
2020年第17期101-102,共2页
Guide of China Medicine
