摘要
目的探讨泮托拉唑联合奥曲肽治疗方案对急性上消化道出血的临床疗效。方法从本院2017年1月至2018年12月接受的急性上消化道出血患者中,抽取52例作为研究对象,按照数字单双原则将其分为对照组(单号)与观察组(双号),各组26例。对照采用泮托拉唑治疗,观察组采用泮托拉唑+奥曲肽联合治疗,观察两组患者上消化道止血时间和输血量、生化指标水平、治疗效果以及不良反应发生情况。结果①观察组患者上消化道止血时间相较于对照组明显更早,输血量相较于对照组更少(P<0.05);②观察组患者治疗后血红蛋白水平、胃液pH值水平相较于对照组均得到了显著提升,生长抑素水平相较于对照组得到了明显降低(P<0.05);③观察组患者治疗总有效率与对照组相比明显更高(P<0.05);④观察组和对照组患者治疗后不良反应发生率均较低,两组相比无明显差异(P>0.05)。结论在急性上消化道出血临床治疗中应用泮托拉唑+奥曲肽联合治疗方案能够有效缩短患者上消化道出血时间、降低输血量和生长抑素水平,提高血红蛋白水平、胃液pH值水平以及治疗效果,且不良反应发生率低,是安全有效的治疗方案。
Objective To investigate the clinical efficacy of pantoprazole combined with octreotide in the treatment of acute upper gastrointestinal bleeding.Methods From January 2017 to December 2018,52 patients with acute upper gastrointestinal hemorrhage were selected as the study subjects and divided into control group(single number)and observation group(double number),26 cases in each group.The control group was treated with pantoprazole,while the observation group was treated with pantoprazole and octreotide.The hemostasis time and blood transfusion volume of upper digestive tract,biochemical index level,therapeutic effect and adverse reactions of the two groups were observed.Result(1)The upper digestive tract hemostasis time of the observation group was obviously earlier than that of the control group,and the blood transfusion volume was less than that of the control group(P<0.05);(2)Compared with the control group,the level of hemoglobin and gastric juice pH were significantly increased,the level of somatostatin was significantly lower than that of the control group(P<0.05).(3)The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);(4)The incidence of adverse reactions of the observation group and the control group after treatment was lower,and there was no significant difference between the two groups(P>0.05).Conclusion Pantoprazole+Octreotide combination therapy can effectively shorten the time of upper gastrointestinal bleeding,reduc blood transfusion volume and somatostatin level,improve of hemoglobin level,gastric juice pH level and therapeutic effect,and the incidence of adverse reactions is low.It is a safe and effective treatment program.
作者
郭钢
GUO Gang(Department of Internal Medicine,Beizhen Second People’s Hospital,Beizhen121308,China)
出处
《中国医药指南》
2020年第17期78-79,共2页
Guide of China Medicine
关键词
泮托拉唑
奥曲肽
急性上消化道出血
止血时间
不良反应
Pantoprazole
Octreotide
Acute upper gastrointestinal bleeding
Hemostatic time
Adverse reactions
Blood
