摘要
目的评估肿瘤合并冠心病经皮冠状动脉介入治疗(PCI)术后高血压患者的临床特点,了解其临床特征,提高临床预后。方法回顾性分析自2008年4月至2019年3月因可疑冠心病于北部战区总医院心血管内科住院且合并肿瘤并行PCI的308例患者的临床资料。按有无高血压将其分为高血压组(n=200)与血压正常组(n=108)。观察并比较两组患者的临床特点及随访期间发生的主要不良心脑血管事件(MACCE)。结果高血压组糖尿病病史、肾功能不全、既往脑卒中病史患者比例均明显高于血压正常组,差异有统计学意义(P<0.05)。高血压组国际标准化比值(INR)、凝血酶原时间(PT)均稍低于血压正常组,而血肌酐水平高于血压正常组,两组比较,差异有统计学意义(P<0.05)。高血压组使用他汀类降脂药、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂、钙离子拮抗剂的患者比例均明显高于血压正常组,组间比较,差异有统计学意义(P<0.05)。在平均(3.41±2.68)年的随访期间,高血压组中靶血管再次血运重建发生率为6.5%(13/200),明显低于血压正常组的10.2%(11/108),差异有统计学意义(P<0.05)。结论肿瘤合并ACS行PCI的高血压患者具有糖尿病病史、卒中病史、肾功能不全病史比例高,INR、PT时间稍短等特点;远期随访发现,靶血管再次血运重建比例低。
Objective To evaluate the clinical characteristics of hypertensive patients with tumor complicated with coronary artery disease after percutaneous coronary intervention(PCI),to understand their clinical characteristics and to improve the clinical prognosis of such patients.Methods A retrospective study was performed on 308 cases of patients with tumor who were admitted from April 2008 to March 2019.The patients were divided into the hypertension group(n=200)and normal blood pressure group(n=108).The clinical characteristics of the two groups of patients and the main unconscionable cerebrovascular events(MACCE)during the follow-up period were observed and compared.Results The proportion of patients with diabetes history,renal insufficiency and previous stroke history in the hypertension group was significantly higher than that in the normal blood pressure group,and the difference was statistically significant(P<0.05).The international standardized ratio(INR)and prothrombin time(PT)of the hypertension group were slightly lower than those of the normal blood pressure group,while the serum creatinine level was higher than that of the normal blood pressure group,P<0.05.The proportion of patients in the hypertension group who received statins,angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers and calcium antagonists was significantly higher than that in the normal group(P<0.05).During the mean(3.41±2.68)years of follow-up,the incidence of target vessel re-revascularization in the hypertension group was 6.5%(13/200),significantly lower than that in the normal group(10.2%,11/108),P<0.05.Conclusion The hypertensive patients with tumor complicated with ACS undergoing PCI have a high proportion of history of diabetes,history of stroke,history of renal insufficiency and a short INR and PT time.In the long-term follow-up,the proportion of target vessel re-revascularization is low.
作者
关明子
王兆丰
刘一飞
赵昕
GUAN Ming-zi;WANG Zhao-feng;LIU Yi-fei;ZHAO Xin(Department of Cardiology,General Hospital of Northern Theater Com-mand,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2020年第5期547-550,555,共5页
Clinical Journal of Medical Officers
基金
辽宁省重点研发计划项目(2018225001)
立信扬帆优化抗栓科研基金(BJUHFCSOARF201801-05)。
关键词
高血压
肿瘤
经皮冠状动脉介入治疗
主要不良心脑血管事件
Hypertension
Tumour
Percutaneous coronary intervention
Major adverse cardiovascular and cerebrovascular events
