摘要
目的:探究DM患者孕晚期外周血中性粒细胞/淋巴细胞比值(NLR)、红细胞分布宽度(RDW)的检测意义。方法:选择2019年1-12月在本院产检且已生产6~12周来复诊的妊娠期糖尿病(GDM)患者63例为研究对象。依据产后6~12周的糖代谢情况,将其分成糖代谢异常组(DM组)33例,糖代谢正常组30例。比较两组孕晚期一般资料及外周血中NLR、RDW,比较两组产后6~12周空腹血糖(FBG)、空腹胰岛素(FINS),并计算稳态模型胰岛素抵抗指数(HOMA-IR)。探究孕晚期外周血中NLR、RDW与产后HOMA-IR及FBG的关系。结果:DM组外周血的NLR、RDW水平均高于糖代谢正常组,差异均有统计学意义(P<0.05)。产后,DM组FBG、FINS、HOMA-IR均高于糖代谢正常组,差异均有统计学意义(P<0.05)。孕妇孕晚期外周血中NLR、RDW与产后HOMA-IR、FBG均呈正相关(P<0.05)。预测产后DM时,NLR联合RDW联合的AUC最高为0.946,优于单一的NLR、RDW,差异均有统计学意义(P<0.05)。结论:产后DM患者孕晚期外周血中NLR、RDW均较糖代谢正常产妇高,NLR、RDW与HOMA-IR、FBG均呈正相关,孕晚期NLR、RDW可作为产后DM的预测指标,且联合检测价值更高,对于高危GDM患者应早预防早干预,改善其预后。
Objective:To explore the significance of the detection of peripheral blood neutrophil-lymphocyte ratio(NLR)and red blood cell volume distribution width(RDW)in DM patients at the third trimester of pregnancy.Method:A total of 63 patients with gestational diabetes mellitus(GDM)who underwent subsequent visit and had been examined in the hospital from January 2019 to December 2019 at 6 to 12 weeks after delivery were selected as the study subjects.According to the glucose metabolism at 6 to 12 weeks after delivery,33 patients were divided into the abnormal glucose metabolism group(DM group)and 30 patients were divided into the normal glucose metabolism group.The general information of late pregnancy and the peripheral blood NLR and RDW of the two groups were compared.Fasting blood glucose(FBG)and fasting insulin(FINS)at 6 to 12 weeks after delivery were compared between the two groups,and the homeostasis model assessment of insulin resistance index(HOMA-IR)was calculated.The relationship between NLR,RDW and HOMA-IR and FBG in peripheral blood in the third trimester of pregnancy were explored.Result:The levels of NLR and RDW in peripheral blood of DM group were higher than those of normal glucose metabolism group,the differences were statistically significant(P<0.05).Postpartum,FBG,FINS,and HOMA-IR in the DM group were all higher than those in the normal glucose metabolism group,the differences were statistically significant(P<0.05).NLR and RDW in peripheral blood of pregnant women in the third trimesteria were positively correlated with HOMA-IR and FBG after delivery(P<0.05).When predicting postpartum DM,the highest AUC of NLR combined with RDW was 0.946,which was better than that of single NLR and RDW,the differences were statistically significant(P<0.05).Conclusion:NLR and RDW in peripheral blood of postpartum DM patients are higher than those of normal glucose metabolism.NLR and RDW are positively correlated with HOMA-IR and FBG.NLR and RDW in the third trimester of pregnancy can be used as predictors of postpartu
作者
符玲玲
李莉
陈昌明
刘振燕
FU Lingling;LI Li;CHEN Changming;LIU Zhenyan(The Third Affiliated Hospital of Guangdong Medical University(Longjiang Hospital,Shunde District,Foshan City),Foshan 528318,China)
出处
《中国医学创新》
CAS
2020年第17期28-32,共5页
Medical Innovation of China
基金
佛山市卫生健康局医学科研课题立项项目(20200244)。
关键词
妊娠期糖尿病
中性粒细胞/淋巴细胞比值
红细胞分布宽度
胰岛素抵抗
Gestational diabetes mellitus
Neutrophil-lymphocyte ratio
Red blood cell volume
distribution width
Insulin resistance
