摘要
哺乳动物肠道分泌大量黏液形成黏液层,其主要成分是黏蛋白2(MUC2)。黏液层对肠道的润滑、保护及强大的屏障功能依赖于MUC2自身的特殊网状结构、性质与功能。肠道MUC2的存在对维系肠腔微环境稳定和肠上皮细胞功能正常具有重要作用。本文综述了肠道MUC2的分泌、结构、合成调控及其在肠道疾病发生发展中的作用,为经调控MUC2防治肠道疾病提供理论依据。
Mucin 2(MUC2)is the main component of mucus,which is secreted by intestinal tract and forms a mucus layer.Mucus layer has protects,lubricates intestinal tract and barrier functions because of the special network structure,properties and functions of MUC2.The presence of intestinal MUC2 is of great value in maintaining the stability of the intestinal microenvironment and normal function of intestinal epithelial cells.This article reviews the secretion,structure,synthesis and regulation of intestinal MUC2 and role in the devel⁃opment of intestinal diseases,and provides a theoretical basis for the regulation of MUC2 in the prevention and treatment of intestinal diseases.
作者
聂烁
闻正顺
NIE Shuo;WEN Zhengshun(School of Food Science and Pharmaceutics,Zhejiang Ocean University,Zhoushan 316022,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2020年第6期2521-2532,共12页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
浙江省属高校基本科研业务费(2019JZ00010)
舟山市科技合作项目(2019C21047)
浙江省重点研发项目(2019C02076)。
关键词
肠道
黏液层
黏蛋白2
肠道疾病
intestinal tract
mucus layer
MUC2
intestinal diseases
