摘要
急性淋巴细胞白血病(ALL)是儿童最常见的恶性肿瘤。大剂量MTX是ALL治疗中最常用的药物之一,但治疗过程中常常产生如溃疡性口炎、恶心、发热和白细胞减少等不良反应。现有研究指出,相关基因通过影响药物代谢酶、靶点、转运体的表达,进而影响MTX的代谢。本文对可能影响MTX代谢的多种基因是否可以准确预测出MTX治疗的不良反应进行综述。
Acute lymphoblastic leukemia(ALL)is the most common malignant tumor in children.High-dose methotrexate is one of the most commonly used drugs in the treatment of ALL,which often produces adverse reactions during treatment,such as ulcerative stomatitis,nausea,fever and leukopenia.The current researches point out that the re-lated genes affect the metabolism of MTX by influencing the expression of drug metabolic enzymes,targets and trans-porter.It is summarized in this article whether multiple genes which affect the metabolism of MTX can accurately pre-dict the adverse reactions of MTX treatment.
作者
孟岑
卢雨昕
徐刚
郝良纯
MENG Cen;LU Yu-xin;XU Gang;HAO Liang-chun(Department of Pediatric Hematology,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《实用药物与临床》
CAS
2020年第6期561-566,共6页
Practical Pharmacy and Clinical Remedies
关键词
急性淋巴细胞白血病
MTX
基因多态性
不良反应
Acute lymphoblastic leukemia
Methotrexate
Genetic polymorphism
Adverse reactions
