摘要
目的 探讨短疗程驱铅方案对人体锌元素及血脂水平的影响。方法 收集2017年12月-2018年10月进行驱铅治疗的轻度铅中毒患者30例,为观察组,同时收集同期健康体检者30例作为对照组。观察组驱铅方案为依地酸二钠钙静脉注射。对比2组基线尿锌及血脂水平;观察组治疗后尿锌及血脂的变化。结果 观察组治疗72 h的尿锌水平高于对照组,差异有统计学意义(P <0. 05);观察组治疗72 h血脂水平与对照组水平基本一致,2组差异无统计学意义(P> 0. 05)。观察组治疗7 d总胆固醇、甘油三脂及低密度脂蛋白高于治疗前水平,差异有统计学意义(P <0. 05)。结论 驱铅方案会造成体内锌元素的丢失,影响血脂水平的波动。
Objective To investigate the levels of zinc element and blood lipid in people treated with short course lead removal plan.Methods The patients with mild lead poisoning treated by eliminating lead from December 2017 to October 2018 were collected and defined as observation group.At the same time,healthy people were collected as control group.The observation group was treated with intravenous injection of disodium calcium edetate.The baseline levels of zinc in urine and blood lipid were compared between the two groups,and the changes of zinc in urine and blood lipid in the observation group after treatment were analyzed.Results There was no statistical significance on the difference in baseline urinary zinc and blood lipid levels between the two groups(P>0.05);the urinary zinc level in the observation group was higher than control group after 72 hours,with the difference statistically significant(P<0.05);the blood lipid level in the observation group was as same as control group after 72 hours,and there was no statistical significance on the difference between the two groups(P>0.05).After 7 days of treatment,the total cholesterol,triglyceride and low density lipoprotein in the observation group were higher than that before treatment,and the results were statistically significant(P<0.05).Conclusion Short course of lead removal plan will lose zinc in the body and affect blood lipid level.
作者
姚君
钟皓成
任娥
周银姬
诸贤含
YAO Jun;ZHONG Hao-cheng;REN E;ZHOU Yin-ji;ZHU Xian-han(Hangzhou Red Cross Hospital,Hangzhou,Zhejiang 310000,China;不详)
出处
《中国卫生检验杂志》
CAS
2020年第10期1183-1185,共3页
Chinese Journal of Health Laboratory Technology
基金
杭州市卫生科技计划(一般)项目(201869544)。
关键词
锌
血脂
铅
Zinc
Blood lipid
Lead
