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Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation 被引量:7

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摘要 Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired"stress-response"method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells.
出处 《Nano Research》 SCIE EI CAS CSCD 2020年第3期795-801,共7页 纳米研究(英文版)
基金 This work was supported primarily by the National Key Research and Development Program of China(No.2018YFE0208500) the Major Research Plan of the National Natural Science Foundation of China(No.91963206) the National Natural Science Foundation of China(Nos.U1508202 and 51627810) the Natural Science Foundation of Jiangsu Province(No.SBK2018022120),the open fund of Wuhan National Laboratory for Optoelectronics(No.2018WNLOKF020) the open fund of Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies(No.EEST2018-1) the civil aerospace technology preliminary research project of the State Administration of Science,Technology and Industry for National Defense.
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