摘要
报告1例31岁女性头部无症状的单发孤立粉红色质软丘疹,丘疹完整切除后组织病理示:真皮内可见由少量梭形、核深染的肿瘤细胞和细胞周围大量黏液样基质构成的分叶状肿瘤团块,包绕纤维性间隔。免疫组化及特殊染色示:NKI/C3、CD10表达强阳性,S-100蛋白、CD68、Desmin、EMA、CEA、Ki76均阴性,阿新兰染色强阳性,Masson三色染色显示肿瘤细胞为红色。诊断:黏液型神经鞘黏液瘤。回顾分析国内外相关文献,有报道认为S-100阴性的黏液型神经鞘黏液瘤是一种新的分型;也有研究认为真正的黏液型NTK并不表达S-100蛋白,而S-100蛋白表达阳性者实际应诊断为真皮神经鞘黏液瘤。
Here we describe a 31-year-old female who had developed an asymptomatic solitary pink soft papule in the head for more than 1 year.Histopathological findings after complete removal of the papule showed that there was a lobulated tumor mass composed of a small amount of spindle shaped cells with hyperchromatic nuclei,as well as a large amount of mucoid matrix,surrounded by fibrous septum in dermis.Immunohistochemistry and special staining showed that NKI/C3 and CD10 were strongly positive,S-100 protein,CD68,desmin,EMA,CEA and ki76 were all negative,Alcian blue staining was strongly positive,Masson trichrome staining showed that the tumor cells were stained red.Diagnosis:myxoid neurothekeoma.According to the relevant literatures at home and abroad,some scholars believed that S-100 negative myxoma is a new type of myxoid neurothekeoma,and the true myxoid neurothekeoma does not express S-100 protein,so the myxoma with positive expression of S-100 protein should be diagnosed as dermis nerve sheath myxoma.
作者
纪明开
张婧
纪超
程波
JI Ming-kai;ZHANG Jing;JI Chao(Department of Dermatology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)
出处
《实用皮肤病学杂志》
2020年第2期115-117,共3页
Journal of Practical Dermatology
