摘要
目的探讨不同分割方式放疗在骨转移肿瘤中的应用效果。方法回顾性分析我院2016年2月至2018年4月收治的80例骨转移肿瘤患者的临床病理资料,所有患者均接受放疗,根据放疗的分割方式分为2组,对照组40例患者采用常规分割方式,观察组40例患者采用大剂量分割方式,比较观察2组患者的临床疗效和不良反应。结果观察组的止痛总有效率为90.0%,对照组为87.5%,比较差异无统计学意义(P>0.05)。观察组胃肠道反应、食欲不振、关节肌肉痛、血小板减少、贫血的发生率分别为20.0%、30.0%、7.5%、40.0%、35.0%,对照组分别为25.0%、27.5%、12.5%、45.0%、37.5%,比较差异均无统计学意义(P均>0.05);2组患者不良反应大多为Ⅰ、Ⅱ度。结论放疗的分割方式对骨转移肿瘤的疗效无明显影响,常规剂量与大剂量的分割方式都能起到良好止痛效果,且安全性高,临床医师应结合患者的病情特点、预计生存期等合理选择放疗分割方式,减轻患者痛苦,提高其生活质量。
Objective To explore the clinical efficacy of radiotherapy with different segmentation methods in the treatment of bone metastases.Methods The clinical data of 80 patients with bone metastases admitted to our hospital from February 2016 to April 2018 were retrospectively collected.All the patients received radiotherapy and were divided into two groups according to the segmentation method of radiotherapy.Forty patients in the control group was treated by routine segmentation radiotherapy,and 40 patients in the observation group were treated by high dose segmentation radiotherapy.The clinical efficacy and toxicities of the two groups were compared.Results The total analgesic effect rate was 90.0%in the observation group,and was 87.5%in the control group(P>0.05).The incidences of gastrointestinal reaction,anorexia,joint muscle pain,thrombocytopenia and anemia in the observation group were respectively 20.0%,30.0%,7.5%,40.0%and 35.0%,while those in the control group were respectively 25.0%,7.5%,12.5%,45.0%and 37.5%,there was no significant difference between the two groups(P>0.05).Most of the adverse reactions in the two groups were gradeⅠtoⅡ.Conclusion Segmentation method of radiotherapy has no significant effect on the curative effect of bone metastasis tumor,conventional dose and high dose of radiotherapy have good analgesic effect and high safety.Clinicians should combine the patient’s condition characteristics and life expectancy to rationally choose the segmentation method of radiotherapy to alleviate the pain of patients and improve the quality of life.
作者
刘慧云
刘东胜
LIU Huiyun;LIU Dongsheng(Department of Oncology,the 988th Hospital,Joint Logistics Support Force of PLA,Zhumadian 463000,China;Department of Radiology,the First People’s Hospital of Zhumadian,Zhumadian 463000,China)
出处
《肿瘤基础与临床》
2020年第2期107-109,共3页
journal of basic and clinical oncology
关键词
分割方式
放疗
骨转移肿瘤
止痛效果
不良反应
segmentation
radiotherapy
bone metastases
analgesic effect
adverse reactions
