摘要
近年来许多研究证实免疫检查点抑制剂在多种癌症治疗中的潜力。自然杀伤细胞(natural killer cell,NK)是固有免疫系统的重要组成部分,在肿瘤免疫监视中发挥重要作用。其作用效应依赖于其与抑制和(或)激动受体的结合,无需主要组织相容性复合体(major histocompatibility complex,MHC)便能有效杀伤肿瘤。NK细胞对实体和血液肿瘤有巨大的杀伤潜力,已被越来越多的研究证实是肿瘤免疫治疗的理想靶点。NK细胞上一些新发现的免疫检查点受体被证实在肿瘤微环境中介导NK细胞的功能障碍,是理想的肿瘤免疫治疗靶点。本文将重点论述近年来新发现的免疫检查点受体在调节NK细胞功能中的作用及其在肿瘤免疫治疗中的潜在应用。
In recent years,many studies have demonstrated the potential of immune checkpoint inhibitors in the treatment of multiple types of cancers.Natural killer(NK)cells are an important part of the innate immune system and play an essential role in tumor immune surveillance.Their effects depend on their binding to inhibitory receptors,activating receptors,or both and the fact that they do not require major histocompatibility complex molecules to kill tumor cells.NK cells have shown great potential against both solid and hematologic tumors and have been increasingly identified as a promising therapeutic target for cancer immunotherapy.Some newly emerging checkpoint receptors and molecules have been revealed to mediate NK cell dysfunction in the tumor microenvironment,making them ideal targets for tumor immunotherapy.Thus,this paper will focus on the roles of these newly emerging immune checkpoint receptors in the regulation of NK cells and their potential application in tumor immunotherapy.
作者
曹雨晴
金添强
田雨
戴朝六(综述)
徐锋(审校)
Yuqing Cao;Tianqiang Jin;Yu Tian;Chaoliu Dai;Feng Xu(Department of General Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2020年第9期472-476,共5页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金(编号:81974377)
辽宁省自然科学基金(编号:20180551193)
盛京医院345人才工程计划资助。
关键词
自然杀伤细胞
免疫检查点
免疫治疗
癌症
natural killer cell(NK)
immune checkpoint
immunotherapy
cancer
