摘要
2019年新型冠状病毒(SARS-CoV-2)引起的病毒性肺炎在中国武汉爆发,对公众健康构成重大威胁。SARS-CoV-2与严重急性呼吸综合征相关冠状病毒(SARS-CoV)和中东呼吸综合征相关冠状病毒(MERS-CoV)高度同源,都会导致严重的呼吸道症状。除呼吸系统症状外,相当比例的SARS和SARS-CoV-2感染者出现不同程度的肝损伤,但其流行病学特征和发生机制尚不明确。在总结SARS-CoV-2流行病学基础上,重点阐述SARS-CoV-2及其所致肝损伤的可能机制和有效治疗方案的研究现状,为SARS-CoV-2感染者肝损伤的防治提供参考和研究思路。
The outbreak of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in Wuhan,China poses a major threat to public health.SARS-CoV-2 is highly homologous to severe acute respiratory syndrome-associated coronavirus and Middle East respiratory syndrome-associated coronavirus,all of which may cause severe respiratory symptoms.In addition to respiratory symptoms,a considerable proportion of patients with SARS and SARS-CoV-2 infection have varying degrees of liver injury,but their epidemiological features and pathogenesis remains unclear.This article summarizes the epidemiology of SARS-CoV-2 and elaborates on the current status of the research on SARS-CoV-2,possible mechanism of liver injury caused by SARS-CoV-2,and effective treatment regimens,so as to provide a reference and new research ideas for the prevention and treatment of liver injury in patients with SARS-CoV-2 infection.
作者
周亚宁
冯巩
刘曼玲
严琴琴
范立萍
弥曼
ZHOU Yaning;FENG Gong;LIU Manling;YAN Qinqin;FAN Liping;MI Man(Graduate School,Xi’an Medical University,Xi’an 710021,China;Institute of General Medicine, Xi’an Medical University, Xi’an 710021, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第6期1402-1406,共5页
Journal of Clinical Hepatology
基金
陕西省普通高等学校优势学科建设项目(陕教位[2014]3号文件)。
关键词
新型冠状病毒
肝损伤
病理过程
治疗学
SARS-CoV-α
liver injury
pathologic processes
therapeutics
