摘要
目的探讨高迁移率族蛋白A2(HMGA2)、糖链抗原19-9(CA19-9)联合ROMA指数对卵巢癌的诊断价值。方法选择2016年3月至2018年3月于河南科技大学第一附属医院行卵巢切除术患者98例为研究对象,其中卵巢癌患者46例(卵巢癌组),良性卵巢疾病患者52例(良性卵巢疾病组);另选择同期体检健康女性50例为健康对照组。采用酶联免疫吸附试验检测受试者血清CA19-9和HMGA2水平,采用全自动电化学发光仪检测血清人附睾蛋白4和糖链抗原125水平,并计算ROMA指数,采用受试者工作特征(ROC)曲线分析血清CA19-9、HMGA2及ROMA指数对卵巢癌的诊断价值。结果卵巢癌组患者血清HMGA2、CA19-9水平和ROMA指数均高于良性卵巢疾病组和健康对照组(P<0.05);良性卵巢疾病组血清HMGA2、CA19-9水平和ROMA指数高于健康对照组(P<0.05)。血清CA19-9、HMGA2水平及ROMA指数与卵巢癌国际妇产科协会分期、淋巴结转移有关(P<0.05),与患者年龄、腹水量及卵巢癌组织学类型无关(P>0.05)。ROC曲线分析显示,血清CA19-9、HMGA2及ROMA指数对卵巢癌的最佳诊断截断点分别为301.76 kU·L^-1、294.13 mg·L^-1、82.48%;血清CA19-9、HMGA2及ROMA指数单独检测诊断卵巢癌的特异性、敏感性、准确度比较差异无统计学意义(P>0.05);血清CA19-9、HMGA2及ROMA指数联合检测诊断卵巢癌的特异性、敏感性、准确度高于三者单独检测(P<0.05)。结论血清HMGA2、CA19-9及ROMA指数联合检测对卵巢癌有一定的诊断价值。
Objective To investigate the diagnostic value of high mobility group protein A2(HMGA2),carbohydrate antigen 19-9(CA19-9)and ROMA index in ovarian cancer.Methods A total of 98 patients who underwent oophorectomy in the First Affiliated Hospital of Henan University of Science and Technology from March 2016 to March 2018 were selected as the study objects,including 46 cases of ovarian cancer(ovarian cancer group)and 52 cases of benign ovarian diseases(benign ovarian disease group).Another 50 healthy women in the same period were selected as the healthy control group.The serum CA19-9 and HMGA2 levels were detected by enzyme-linked immunosorbent assay,the levels of serum human epididymal protein 4 and carbohydrate antigen 125 were detected by automatic electrochemiluminescence apparatus,and the ROMA index was calculated.The diagnostic value of serum CA19-9,HMGA2 and ROMA index in ovarian cancer was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum HMGA2,CA19-9 and ROMA index in the ovarian cancer group were higher than those in the benign ovarian disease group and healthy control group(P<0.05).The levels of serum HMGA2,CA19-9 and ROMA index in the benign ovarian disease group were higher than those in the healthy control group(P<0.05).The levels of serum CA19-9,HMGA2 and ROMA index were related to federation international of gynecology and obstetrics staging and lymph node metastasis of ovarian cancer(P<0.05),but they were not related to the age,ascites volume of the patients and histological type of ovarian cancer(P>0.05).ROC curve analysis showed that the best cut-off points of the serum CA19-9,HMGA2 levels and ROMA index were 301.76 kU·L^-1,294.13 mg·L^-1 and 82.48%,respectively.There was no significant difference in the specificity,sensitivity and accuracy of the separately detection of serum CA19-9,HMGA2 and ROMA index in the diagnosis of ovarian cancer(P>0.05).The specificity,sensitivity and accuracy of the combined detection of serum CA19-9,HMGA2 and ROMA index in the diagnos
作者
张镛镛
王芳
雷利娜
薛秀珍
ZHANG Yongyong;WANG Fang;LEI Lina;XUE Xiuzhen(Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China;Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)
出处
《新乡医学院学报》
CAS
2020年第5期471-474,共4页
Journal of Xinxiang Medical University
基金
河南省医学科技攻关计划项目(编号:2018020157)。
