摘要
非酒精性脂肪性肝病(NAFLD)是指很少或没有饮酒的情况下超过5%的肝细胞存在脂肪变性的一系列肝脏疾病。对NAFLD病理机制的解释已发展为“多次打击”学说,强调了内质网应激在NAFLD发展中的作用。本文对内质网应激和NAFLD的研究进展作出综述。
Nonalcoholic fatty liver disease(NAFLD)is a series of liver diseases that are defined as the presence of steatosis in more than 5%of hepatocytes with little or no alcohol consumption.The interpretation of the pathological mechanism of NAFLD has evolved into a“multiple strikes”doctrine,emphasizing the role of endoplasmic reticulum stress in the development of NAFLD.This article reviews the research progress of endoplasmic reticulum stress and NAFLD.
作者
霍兆炯
吴斐华
HUO Zhao-jiong;WU Fei-hua(Department of Pharmacology of Chinese Materia Medica,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《海峡药学》
2020年第5期1-4,共4页
Strait Pharmaceutical Journal
基金
江苏省研究生科研与实践创新计划(KYCX18_0829)。
关键词
非酒精性脂肪肝
内质网应激
胰岛素抵抗
炎症
凋亡
Nonalcoholic fatty liver
Endoplasmic reticulum stress
Insulin resistance
Inflammation
Apoptosis
