摘要
目的探讨人乳头瘤病毒(HPV)在男性感染者中的基因型分布特点。方法利用PCR⁃反向点杂交法对571例男性HPV感染者进行基因分型检测。结果HPV低危型感染中,6、11和42型是主要感染亚型,高危型感染中,52、16和51是主要感染亚型;不同年龄段感染者中,21~40岁年龄的男性HPV感染率最高;不同类型感染中,单一感染率为56.39%,多重感染(二重及以上)感染率为43.61%,单一感染率高;多重感染中,共检测到7种不同的感染类型,其中二重感染和三重感染的感染率最高,且以高低危混合感染为主。结论男性感染者的HPV基因型在不同年龄段和不同感染类型分布上有明显差异,21~40岁感染率最高且感染类型较为复杂。
Objective To investigate the genotype distribution of HPV infection in male persons.Methods Genotyping of 571 males infected with HPV infected by PCR⁃reverse dot blot hybridization.Results Among the low⁃risk HPV infections,genotype 6,11 and 42 were the major subtypes of infection.Among the high⁃risk infections,genotype 52,16 and 51 were the major subtypes of infection.Among different age groups infected,HPV in males aged 21-40 have the highest rate of HPV infection.Among different types of infection,the single infection rate was 56.39%,multiple(double and above)infection rate was 43.61%,and the single infection rate was high.In multiple infections,7 different types of infections were detected,double and triple infection ratesare the highest.High and low risk of mixed infection accounted for the majority.Conclusion The HPV genotypes of male infected persons are significantly different in different age groups and different infection types.The infection rate is the highest among 21-40 years old and the infection types are more complicated.
作者
吕家庆
胡俊杰
符生苗
陈鑫苹
LV Jiaqing;HU Junjie;FU Shengmiao;CHEN Xinping(Department of Clinical Laboratory,Nada Town Hospital,Danzhou city,Danzhou,Hainan,China,571700;Central Laboratory,Hainan General hospital,Hainan Hospital Affiliated to The Hainan Medical College,Haikou,Hainan Province 570311,China)
出处
《分子诊断与治疗杂志》
2020年第2期146-150,共5页
Journal of Molecular Diagnostics and Therapy
