摘要
目的通过分析抗核抗体(ANA)和抗核抗体谱(ANAs)在不明原因复发性流产(URSA)患者血清中的表达情况,探讨ANA及ANAs与不明原因复发性流产的发生是否具有相关性。方法选取流产门诊就诊的不明原因复发性流产患者267例作为观察组,另选取同期有正常妊娠分娩史的女性90例作为对照组。采用化学发光法检测并比较两组血清中ANA和ANAs的阳性情况。结果观察组血清样本ANA阳性57例,阳性率为21.35%;对照组血清样本ANA阳性2例,阳性率为2.22%。两组ANA阳性率比较,差异有统计学意义(P<0.05)。观察组抗干燥综合征抗原A抗体(SSA)、抗干燥综合征抗原B抗体(SSB)、抗双链DNA抗体(dsDNA)阳性率分别为6.37%(17/267)、0.75%(2/267)、3.00%(8/267),抗史密斯抗体(Sm)、抗硬皮病70抗体(Scl-70)、抗组氨酰t RNA合成酶抗体(Jo-1)阳性率均为0。对照组SSA阳性率为2.22%(2/90), Sm、SSB、Scl-70、Jo-1、dsDNA阳性率均为0。两组Sm、SSA、SSB、Scl-70、Jo-1、dsDNA阳性率比较,差异均无统计学意义(P>0.05)。结论自身抗体ANA和不明原因复发性流产的发生发展有一定的相关性,临床上可能是反复流产的原因之一,但具体的机制机理尚需进一步明确。
Objective Objective To discuss the correlation between antinuclear antibody(ANA) and antinuclear antibody spectrum(ANAs) and unexplained recurrent abortion by analyzing the expression of ANA and ANAs in the serum of patients with unexplained recurrent spontaneous abortion(URSA). Methods There were 267 patients with unexplained recurrent spontaneous abortion selected as the observation group and 90 women with normal pregnancy and delivery history as the control group. The chemiluminescence method was used to detect and compare the positive status of ANA and ANAs in the two groups of serum. Results The observation group had 57 ANA positive cases, with positive rate as 21.35%. The control group had 2 ANA positive cases, with positive rate as 2.22%. There was statistically significant difference in ANA positive rate between the two groups(P<0.05). The positive rates of anti Sjogren’s syndrome antigen A antibody(SSA), anti Sjogren’s syndrome antigen B antibody(SSB), anti dsDNA antibody(dsDNA) were 6.37%(17/267), 0.75%(2/267), 3.00%(8/267), and the positive rates of anti Smith’s antibody(Sm), anti scleroderma 70 antibody(Scl-70) and anti histidine tRNA synthetase antibody(Jo-1) were 0. The control group had SSA positive rate as 2.22%(2/90), Sm, SSB, Scl-70, Jo-1 and dsDNA positive rate as 0. There was no statistically significant difference in Sm, SSA, SSB, Scl-70, Jo-1, dsDNA postive rate between the two groups(P>0.05). Conclusion There is a certain correlation between ANA and the occurrence and development of unexplained recurrent spontaneous abortion. It may be one of the causes of recurrent abortion in clinic, but the specific mechanism needs to be further clarified.
作者
崔蓉
钟兴明
苗竹林
韩璐
刘晓阳
王永霞
CUI Rong;ZHONG Xing-ming;MIAO Zhu-lin(Guangdong Family Planning Research Institute,Guangzhou 510600,China)
出处
《中国实用医药》
2020年第13期1-3,共3页
China Practical Medicine
关键词
抗核抗体
抗核抗体谱
不明原因复发性流产
Antinuclear antibody
Antinuclear antibody spectrum
Unexplained recurrent spontaneous abortion
