摘要
BACKGROUND Vitamin D deficiency is common in patients with chronic pain and healthy people,but the difference between the two has not been reported;thus,whether there is a relationship between vitamin D deficiency and chronic pain remains to be confirmed.Osteoporosis is a common disease in chronic pain disorders.Understanding the relationship between vitamin D and osteoporosis will provide a basis for the rational supplementation of vitamin D to prevent osteoporosis,and to understand the risk factors of bone mass change to provide a new treatment plan for early prevention of osteoporosis.AIM To determine 25 hydroxy vitamin D(25OHD)level in patients with chronic pain to clarify its clinical significance.The relationship between vitamin D and bone mineral density(BMD)and the risk factors for bone mass change were also evaluated.METHODS In this study,184 patients with chronic pain were included in the study group,and 104 healthy individuals who underwent routine health checkups during the same period were included in the control group.25OHD level was detected in both groups by enzyme-linked immunosorbent assay.According to the BMD test results,the patients in the study group were further classified into three subgroups:Normal BMD group,reduced BMD group,and osteoporosis group.Age,sex,ethnicity,living altitude,body mass index,25OHD level,parathyroid hormone(PTH),calcium(Ca)and phosphorus levels were analyzed statistically in both groups.RESULTS The vitamin D level in the study group was lower than that in the control group at 53.8%vs 57.7%,with no significant difference between the two groups.The proportion of patients with severe vitamin D deficiency in the study group was higher than that in the control group.The mean age was greater in the osteoporosis subgroup,and the youngest in the normal BMD subgroup.Vitamin D level in the osteoporosis subgroup was lower than that in the other two subgroups,and was not specific for the diagnosis of bone mass reduction and osteoporosis.The above results were analyzed statistica
基金
Supported by the 2016 Guidance Project of Qinghai Provincial Health and Family Planning Commission,No.2016-wjzdx-14.
