摘要
目的分析新疆某院围产期(孕35~37周)孕妇B族链球菌(GBS)与支原体共感染情况及药物敏感性,为临床抗感染治疗提供参考。方法选取2017年12月-2018年8月新疆维吾尔自治区人民医院孕35~37周孕妇894例。采用培养法检测细菌和真菌,采用肉汤增菌培养法检测GBS,采用人工培养法检测支原体。结果894例孕妇中,GBS感染65例,解脲支原体(Uu)感染41例,二者共感染33例;细菌感染(118例)以GBS感染为主,混合感染(56例)以GBS+Uu为主;65株GBS对利奈唑胺、青霉素、万古霉素、美罗培南、氨苄西林、头孢曲松的敏感率均为100%,检出对左氧氟沙星、四环素和克林霉素中介株,对克林霉素的耐药率最高(86.15%);41株Uu对美满霉素、强力霉素、罗红霉素、交沙霉素和克拉霉素的敏感率均为100%,检出对环丙沙星、司帕沙星、氧氟沙星、阿奇霉素、壮观霉素、左氧氟沙星和诺氟沙星中介株,对环丙沙星的耐药率最高(92.68%)。结论新疆维吾尔自治区人民医院围产期孕妇GBS和Uu感染较普遍,且多为GBS+Uu共感染。GBS对克林霉素的耐药率较高,Uu对环丙沙星的耐药情况严重,临床对此应加以重视。
Objective To analyze the characteristics of co-infection and drug susceptibility of group B Streptococcus(GBS)and Mycoplasma in perinatal women from 35 to 37 gestational weeks.Methods A total of 894 perinatal women from 35 to 37 gestational weeks in the People's Hospital of Xinjiang Uygur Autonomous Region from December 2017 to August 2018 were enrolled.Bacteria and fungi were determined by culture method.GBS was determined by broth enrichment culture automatic determination method,and Mycoplasma was determined by artificial culture method.Results In the 894 perinatal women,there were 65 cases of GBS infection and 41 cases of Ureaplasma urealyticum(Uu)infection,and there were 33 cases of co-infection.In bacterial infection(118 cases),GBS was mainly,and in mixed infection(56 cases),GBS+Uu was mainly.Totally,65 isolates of GBS were sensitive to linezolid,penicillin,vancomycin,meropenem,ampicillin and ceftriaxone,and the sensitive rates were 100%.The mediated isolates of levofloxacin,tetracycline and clindamycin were determined,and the drug resistance rate to clindamycin was the highest(86.15%).Totally,41 isolates of Uu were sensitive to minocycline,doxycycline,roxithromycin,josamycin,and the sensitive rates were 100%.The mediated isolates of ciprofloxacin,sparfloxacin,ofloxacin,azithromycin,spectinomycin,levofloxacin and norfloxacin were determined,and the drug resistance rate to ciprofloxacin was the highest(92.68%).Conclusions There are many infections of GBS and Uu in perinatal women in the People's Hospital of Xinjiang Uygur Autonomous Region,and the 2 infections are common.The drug resistance rate of GBS to clindamycin is high,and the drug resistance of Uu to ciprofloxacin is serious.Those should be taken seriously.
作者
郭淑丽
罗先道
贾海英
杨丽玮
黄国虹
王昌敏
GUO Shuli;LUO Xiandao;JIA Haiying;YANG Liwei;HUANG Guohong;WANG Changmin(Clinical Laboratory Center,the People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang,China;The Third Department of Cardiology,Urumqi Friendship Hospital,Urumqi 830001,Xinjiang,China)
出处
《检验医学》
CAS
2020年第5期451-454,共4页
Laboratory Medicine
基金
自然科学基金项目(2018D01C118)。
关键词
围产期
B族链球菌
支原体
共感染
药物敏感性
Perinatal stage
Group B Streptococcus
Mycoplasma
Co-infection
Drug susceptibility
