摘要
目的 探讨在难治性精神分裂症治疗中运用利培酮及奥氮平的效果及临床药学分析.方法 采用计算机随机抽样分组的方式将2017年1月~2019年2月广东省茂名市第三人民医院精神科难治性精神分裂症60例患者分为利培酮组(n=30,利培酮治疗)与奥氮平组(n=30,奥氮平治疗),分析效果.结果 奥氮平组总有效率及治疗后HVLT-R、WMS评分与利培酮组比较,差异无统计学意义(P>0.05).奥氮平组治疗后WCST评分与利培酮组比较更高,差异有统计学意义(P<0.05).奥氮平组中体重增加、嗜睡发生率与利培酮组比较更高,奥氮平组中锥体外系反应、头晕头疼发生率与利培酮组比较更低,差异有统计学意义(P<0.05).结论 对难治性精神分裂症患者运用利培酮与奥氮平治疗疗效相当,但奥氮平对执行能力改善效果更好,用药中易出现体重增加、嗜睡.
Objective To explore the efficacy of risperidone and olanzapine in the treatment of refractory schizophrenia and clinical pharmaceutical analysis.Methods Sixty patients with refractory schizophrenia admitted to Maoming Third People’s Hospital of Guangdong from January 2017 to February 2019 were selected using the random sampling and grouping with computer and divided into two groups:risperidone group(n=30,treatment with risperidone)and olanzapine group(n=30,treatment with olanzapine)to analyze efficacyrespectively.Results By comparing the overall response rate,post-treatment HVLT-R and WMS scores between olanzapine group and risperidone group,the differenceswere not statistically significant(P>0.05).In inter-group comparison,posttreatment WCST score of olanzapine group was higher than that of risperidone group,the differencewas statistically significant(P<0.05).The weight gain and incidence of drowsiness of olanzapine group were higher than those of risperidone group by inter-group comparison,while the incidences of extrapyramidal reaction,dizziness and headache of olanzapine group were higher than those of risperidone group by inter-group comparison,the differences were statistically significant(P<0.05).Conclusion Administration of risperidone and olanzapine in patients with refractory schizophrenia has comparable efficacy,but the improvement of executive capability induced by olanzapine issuperior torisperidone.However it’s easy to develop weight gain and drowsiness during administration.
作者
黄春燕
HUANG Chunyan(Pharmacy Department of Maoming Third People’s Hospital,Guangdong,Maoming 525000,China)
出处
《中国医药科学》
2020年第10期57-59,91,共4页
China Medicine And Pharmacy
关键词
难治性精神分裂症
利培酮
奥氮平
药学
认知功能
Refractory schizophrenia
Risperidone
Olanzapine
Pharmacy
Cognitive function
