摘要
目的观察针刺治疗慢性盆腔炎所致盆腔痛的临床疗效及对免疫细胞、血清炎性因子的影响。方法选取多中心2016年1月—2018年12月收治的144例慢性盆腔炎所致慢性盆腔痛(CPP)患者纳入本研究,依据随机数字法将入选患者进行平均分配,分别纳入常规组与针刺组,常规组给予布洛芬缓释胶囊治疗,针刺组在常规组的基础上给予针刺治疗。治疗1个疗程后,评估两组临床疗效,观察两组患者治疗前后疼痛程度、中医证候积分、免疫T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)水平、血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、C反应蛋白(CRP)]表达水平、局部体征分级评分及生活质量的变化,并统计治疗期间不良反应发生情况。结果针刺组治疗后总有效率与整体疗效水平均优于常规组(P<0.05);两组治疗后下腹、腰骶部疼痛视觉模拟评分(VAS评分)、中医证候积分、血清炎性因子(TNF-α、IL-2、CRP)表达水平、免疫T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)水平、局部体征分级评分、世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分均较本组治疗前改善,且针刺组优于常规组(P<0.05);针刺组不良反应发生率为6.94%,常规组为9.72%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论针刺治疗慢性盆腔炎所致盆腔痛疗效良好,可有效降低患者血清促炎因子的表达水平,减轻疼痛程度,改善中医证候与局部体征,全面提升患者生活质量。
Objective To observe the clinical effect of acupuncture on pelvic pain caused by chronic pelvic inflammation and its effect on serum inflammatory factors.Methods A total of 144 patients with chronic pelvic pain(CPP)due to chronic pelvic inflammatory disease who were admitted to the multicenter from January 2016 to December 2018 were included in this study.The selected patients were devided into the conventional group and the acupuncture group according to the random number method into conventional group and acupuncture group,The conventional group was given ibuprofen sustained-release capsule,and the acupuncture group was given acupuncture treatment on the basis of the conventional group.After one course of treatment,the clinical efficacy of the two groups was evaluated.Changes in pain degree,TCM syndromes,immune cells,serum inflammatory factors,local signs grading and life quality of the patients in the two groups before and after treatment were observed.TCM syndromes,immune T cell subsets(CD4^+,CD8^+,CD4^+/CD8^+)levels,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),C response Protein(CRP)]changes in expression levels,local signs and quality of life,and statistics of adverse reactions during treatment were studied.Results The total effective rate was 95.83%in the acupuncture group and 84.72%in the conventional group.The total effective rate and overall therapeutic effect of the acupuncture group were both better than that of the conventional group,with statistically significant differences(P<0.05).After treatment,the visual analogue scoring method(VAS score)of the lower abdomen and lumbosacral pain after treatment in both groups,,TCM syndrome score,and serum inflammation Factor(TNF-α,IL-2,CRP)expression levels,immune T cell subsets(CD4^+,CD8^+,CD4^+/CD8^+)levels,local sign grading scores,World Health Organization Quality of Life Scale Scale(WHOQOL-BREF)were all improved in the two groups compared with the group before treatment.The acupuncture group was better than the conventio
作者
田璐
王昕
TIAN Lu;WANG Xin(Department of Obstetrics and Gynecology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110032)
出处
《世界中西医结合杂志》
2020年第5期785-789,共5页
World Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局国家中医临床研究项目(JDZX2015064)。
关键词
慢性盆腔炎
盆腔痛
针刺
炎性因子
Chronic pelvic inflammatory disease
Chronic pelvic pain
Acupuncture
Inflammatory factors
