摘要
随着药物性肝损伤患病率的逐年上升,药物性肝损伤发病机制成为了关注的焦点。CYP450酶作为一个庞大的家族,参与了药物在人体肝脏内的几乎所有氧化代谢反应。近年来发现CYP450酶的基因多态性导致了药效动力学在不同个体中的代谢差异性,故探索CYP450酶基因多态性在药物性肝损伤中的作用,可促进对药物性肝损伤发病机制的了解。对已发现与药物性肝损伤相关的CYP450酶基因多态性进行综述。
As the prevalence rate of drug-induced liver injury increases year by year,the pathogenesis of drug-induced liver injury has become the focus of attention.As a large family,CYP450 enzymes participate in almost all oxidative metabolic reactions of drugs in the human liver.Recent studies have shown that CYP450 enzyme gene polymorphisms lead to the differences in pharmacodynamics between individuals,and therefore,exploring the role of CYP450 enzyme gene polymorphisms in drug-induced liver injury may promote the understanding of the pathogenesis of drug-induced liver injury.This article reviews the CYP450 enzyme polymorphisms that have been found to be associated with drug-induced liver injury.
作者
王巧玲
邹正升
WANG Qiaoling;ZOU Zhengsheng(Peking University Health Science Center, Beijing 100071, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第5期1150-1153,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(81670527)。
