摘要
肺炎链球菌神经氨酸酶A(neuraminidase A,NanA)是由1035个氨基酸组成的多肽蛋白,是肺炎链球菌感染过程中的重要毒力因子。该蛋白在肺炎链球菌3种同源神经氨酸酶(NanA、NanB、NanC)中活性最强、保守性最高。文章从NanA的结构以及NanA在促进肺炎球菌黏附与定植、生物膜形成、引发侵袭性感染和与流感病毒协同作用、疫苗应用等方面阐述了肺炎链球菌NanA的功能。
Neuraminidase A(NanA)is an important virulence factor of Streptococcus pneumoniae that is composed of 1035 amino acids.It is the most active and conservative protein among the three homologous neuraminidases(NanA,NanB and NanC).This paper describes the structure of NanA and its role in promoting pneumococcal adhesion and colonization,biofilm formation,inducing invasive infection,synergizing with influenza viruses and vaccine application.
作者
殷庭萱
李艺然
刘志伊
徐岩
贾文宁
刘金辉
YIN Ting-xuan;LI Yi-ran;LIU Zhi-yi;XU Yan;JIA Wen-ning;LIU Jin-hui(2017 Grade of Medical Department of Queen Mary College,Nanchang University,Nanchang 330006,China;Department of Medical Microbiology of Medical College,Nanchang University,Nanchang 330006,China)
出处
《实用临床医学（江西）》
CAS
2020年第3期86-90,共5页
Practical Clinical Medicine
基金
南昌大学大学生创新创业项目(2019年)(2019042263)。
关键词
肺炎链球菌
神经氨酸酶
毒力
感染
Streptococcus pneumoniae
neuraminidase
virulence
infection
