摘要
介绍了非水相生物催化的现状,包括常用催化剂种类如游离酶、固定化酶和全细胞催化剂,常见的非水相催化介质如有机溶剂体系、无溶剂体系、离子液体体系以及超临界流体介质体系,阐述了糖苷类化合物的去糖基化修饰、糖基化修饰、酰化修饰以及甲基化修饰等方法,并叙述了结构修饰对化合物性质的影响,如提高化合物的溶解度、增强化合物的稳定性以及提升化合物的生物活性等,简单介绍了目前糖苷类结构修饰化合物的相关应用。
This paper introduced the present situation of biological catalysis in non-aqueous phase.The common biological catalysts including free enzyme,immobilized enzyme and whole cell catalyst were presented in detail.Four kinds of catalytic media in non-aqueous phase including organic solvent system,solvent-free system,ionic liquid system and supercritical fluid medium system were described.And the deglycosylation,glycosylation,acylation modifications and methylation of glycoside compounds were expounded.This paper also described the effects of structural modification on the properties of the compounds,such as improving the solubility,enhancing the stability and promoting the biological activity of these compounds.The related applications of glycoside compounds with structural modification were briefly introduced.
作者
杨荣玲
吴婷婷
赵祥杰
聂泽坤
王朝宇
YANG Rongling;WU Tingting;ZHAO Xiangjie;NIE Zekun;WANG Zhaoyu(Huaiyin Institute of Technology,School of Life Science and Food Technology, Huai′an 223003, China)
出处
《生物质化学工程》
CAS
北大核心
2020年第3期54-60,共7页
Biomass Chemical Engineering
基金
国家自然科学基金资助项目(21706088)
江苏省自然科学基金青年基金项目(BK20170458)
江苏省“六大人才高峰”项目(2018-SWYY-020)。
关键词
非水相
生物催化
糖苷类化合物
结构修饰
进展
non-aqueous phase
biocatalytic
glycoside compounds
structural modification
advance
