摘要
目的:测算甲状腺功能亢进症患者的血浆中超氧化物歧化酶(SOD)水平,并评估甲亢患者SOD变化的临床意义。方法:选择57例确诊住院的甲状腺功能亢进症患者和33例同一时期在我院健康体检的正常者为研究对象。分别检测两组人群的血清SOD、甲状腺功能及其他临床指标。采用Pearson相关及多元逐步线性回归分析SOD与各临床指标间的关系。结果:甲亢患者血清SOD水平(120.25±9.50)U/mL较正常对照组(144.79±11.01)U/mL降低(P<0.05)。甲亢患者的SOD水平与患者的年龄、游离三碘甲状腺原氨酸(FT 3)、游离甲状腺素(FT 4)、谷丙转氨酶(ALT)以及谷草转氨酶(AST)呈负相关(P<0.05)。在校正性别、体质量后,多元逐步线性回归表明甲亢患者的FT 4和年龄为SOD水平的主要影响因素。结论:甲亢患者体内SOD水平与甲状腺功能密切相关。
Objective:To evaluate the clinical implications of superoxide dismutase(SOD)level in patients with hyperthyroidism patients by measuring SDD variation.Methods:Fifty patients with hyperthyroidism and 33 healthy subjects undergoing physical examination in our hospital were included,and underwent serum SOD,thyroid function and other clinical indicators.Pearson correlation and multiple stepwise linear regression were used to analyze the correlation between SOD and related clinical indicators.Results:Serum SOD level was significantly lower in hyperthyroidism patients than in controls[(120.25±9.50)U/mL vs.(144.79±11.01)U/mL,P<0.05)],and SOD level in hyperthyroidism patients was negatively correlated with age,levels of free triiodothyronine(FT3),free thyroxine(FT4),glutamic pyruvic transaminase(ALT)and aspartate aminotransferase(AST)(P<0.05).After adjusting for gender and body weight,multiple stepwise linear regression showed that FT4 and age were the major factors affecting SOD level in patients with hyperthyroidism.Conclusion:SOD level is strongly associated with thyroid function in patients with hyperthyroidism.
作者
孟祥健
华强
何俊俊
姚新明
高家林
MENG Xiangjian;HUA Qiang;HE Junjun;YAO Xinming;GAO Jialin(Department of Endocrinology,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2020年第2期129-132,共4页
Journal of Wannan Medical College
基金
国家自然科学基金面上项目(81471002)
皖南医学院重点科研基金项目(WK2019ZF06)。
关键词
甲亢
超氧化物歧化酶
甲状腺功能
hyperthyroidism
superoxide dismutase
thyroid function
