摘要
目的:检测PD-L1在皮肤鳞状细胞癌(cSCC)及角化棘皮瘤(KA)中的表达,分析PD-L1与cSCC分化程度的相关性。方法:免疫组化染色检测PD-L1在cSCC及KA中表达水平。结果:共检测56例cSCC患者和32例KA患者标本,PD-L1在cSCC组和KA组中的阳性率分别为66.07%和62.50%,均显著高于正常对照组(9.38%)(P s<0.01)。PD-L1阳性率在cSCC与KA组的差异没有统计学意义(P>0.05)。PD-L1的表达强度与cSCC的分化程度呈负相关(P<0.05)。结论:PD-L1不能作为区分cSCC与KA的指标。PD-L1的表达强度与cSCC分化程度呈负相关。
Objective:To detect the level of PD-L1 in the patients with cutaneous squamous cell carcinoma(cSCC)and keratoacanthoma(KA),and to analyze the correlation between PD-L1 and the differentiation of cSCC.Methods:The expression level of PD-L1 in the lesions of cSCC and KA was detected by immunohistochemical staining.Results:Fifty-six patients with cSCC and 32 patients with KA were collected.The positivity rates of PD-L1 in cSCC patients were 66.07% and 62.50% in KA patients,which was significantly higher than that in controls(9.38%)(P s<0.01).There was no significant difference in the positivity rate of PD-L1 between cSCC and KA patients(P>0.05).The level of PD-L1 was negatively correlated with the differentiation degree of cSCC(P<0.05).Conclusion:PD-L1 may not be a useful indicator for the differnece between cSCC and KA.The level of PD-L1 was negatively correlated with the differentiation degree of cSCC.
作者
胡婕
陈伟
卢平
程双华
李灿
HU Jie;CHEN Wei;LU Ping;CHENG Shuanghua;LI Can(Department of Pathology,The Second Affiliated Hospital of Chengdu Medical College,National Nuclear Corporation of 416 Hospital,Chengdu 610051,China)
出处
《中国麻风皮肤病杂志》
2020年第6期335-338,共4页
China Journal of Leprosy and Skin Diseases
基金
成都市卫生和计划生育委员会科研课题(编号:2018070)。
