摘要
目的探讨过度瘦身对女性生殖的危害性,警示女性不能瘦身太过,保存生育年龄应有的生育功能。方法通过实验造成雌鼠消瘦状态,模拟女性过度减肥体重下降过程,以卵巢VEGF、Bcl-2/Bax等为切入点,探讨生殖功能受损的体重下降预警线。结果“左旋肉碱+半量饮食+过度运动”可造成大鼠过度瘦身模型;体重下降的幅度与卵巢功能呈正相关;当造模8周体重下降23%时,血清性激素水平及卵巢VEGF的表达量明显下降,给予恢复饮食及药物干预逆转不明显。结论过度瘦身对女性生殖具有危害性,早期给予恢复饮食及左归丸可以一定程度逆转卵巢功能。
Objective To discuss the harmfulness of excessive weight loss and caution the women against it so as to maintain the reproductive function at the age of childbearing.Method To cause the rats emaciated by means of lab experiment and emulate the progress of female excessive weight loss to explore the warning level due to the reproductive function damage,starting from the VEGF,Bcl-2/Bax of the ovaries.Result L-carnitine plus half diet and excessive exercise can cause the rats to overtly lose weight.The range of weight loss is positive correlation of the ovary’s function.Serum sex hormone levels and the VEGF of ovary expression quantity dramatically decline,and the reversal is not apparent if the diet and medication is recovered.Conclusion Excessive weight loss causes the damage to female bodies,but the early recovery of diet plus Zuo Gui Pill can reverse the function of ovary to some extent.
作者
崔晓萍
肖新春
刘霞
高洒洒
王艳萍
张昕
刘露
范美玲
吴小燕
Cui Xiaoping;Xiao Xinchun;Liu Xia;Gao Sasa;Wang Yanping;Zhang Xin;Liu Lu;Fan Meiling;Wu Xiaoyan(The First Hospital Affiliated to Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046)
出处
《陕西中医药大学学报》
2020年第3期56-61,共6页
Journal of Shaanxi University of Chinese Medicine
基金
国家自然科学基金资助项目(81373681)
陕西省自然科学基础研究计划项目(2017JM8091)。
