摘要
目的探讨广州市新冠肺炎(COVID-19)密切接触者感染的危险因素,为分类管理提供科学依据。方法纳入2020年1月24日-3月2日广州市报告的新冠肺炎确诊病例、疑似病例、阳性检测者相关的密切接触者共2 593人,收集密切接触者一般人口学信息、暴露信息及转归等信息。比较不同转归密切接触者的人口学和流行病学特征,采用多因素logistic回归分析密切接触者感染的危险因素。结果共127例转归为新冠肺炎确诊病例或阳性检测者,占全部报告病例的36.71%(127/346);与关联病例最主要的社会关系为家庭亲属关系(88.98%,113/127);最主要的接触地点为家中(81.89%,104/127);90.55%(115/127)的密接感染者与关联病例经常接触,主要接触方式依次是同餐、同住、同屋,分别占84.25%(107/127)、69.29%(88/127)和60.63%(77/127)。logistic回归分析显示家人亲属关系(OR=4.331,95%CI=1.009~17.063))、同餐(OR=2.030,95%CI=1.037~3.975)、年龄(OR=1.205,95%CI=1.095~1.326)和经常接触(OR=5.516,95%CI=3.180~9.569)是密切接触者感染的危险因素。结论提倡家庭内个人卫生习惯、加强物表消毒、保持安全社交距离、及早集中隔离医学观察是切断家庭内传播的重要措施。建立密接者管理的风险等级评估标准,可指导分类管理、精准防控。
Objective To explore risk factors of 2019 novel coronavirus(2019-nCoV) infection for close contacts of 2019 novel coronavirus disease(COVID-19) cases in Guangzhou city. Methods We enrolled 2 593 close contacts of confirmed,suspected, and asymptomatic COVID-19 cases diagnosed from January 24 to March 2, 2020 in Guangzhou city of Guangdong province. The contacts’ information on demographics, exposure history, and quarantine outcomes were collected and analyzed with descriptive statistics and logistic regression. Results Among all the contacts, 127 were diagnosed as confirmed or asymptomatic COVID-19 cases within the 14-day medical observation, accounting for 36.71%(127/346) of all the COVID-19 cases diagnosed during the period. Of all the confirmed infectees, 113(88.98%) were the infectors′ family members or relatives;104(81.89%) were exposed to the infectors in family settings;115(90.55%) had frequent contacts with the infectors;and 107(84.25%), 88(69.29%), and 77(60.63%) reported ever dining, living, and using the same bedroom together with the infector, respectively. Logistic regression analysis revealed following significant risk factors of the infection for the close contacts: being an infector′ s family member or relative(odds ratio [OR] = 4.331, 95% confidence interval[95% CI]: 1.009-17.063), dining together with an infector(OR = 2.030, 95% CI: 1.037-3.975), at elder age(OR = 1.205,95% CI: 1.095-1.326), and frequent contact(OR = 5.516, 95% CI: 3.180-9.569). Conclusion The important measures to cut off the spread of the disease in the family are to promoting personal hygienic habit, conducting disinfection of commodities, keeping safe social distance, and having early medical observation are important measure to prevent familial transmission of the coronavirus disease.
作者
马钰
马蒙蒙
罗业飞
刘方华
杨韵鸥
陈思宇
景钦隆
罗雷
张周斌
MA Yu;MA Meng-meng;LUO Ye-fei(Department of Infectious Disease Control and Prevention,Guangzhou Municipal Center for Disease Control and Prevention,Guangzhou,Guangdong Province 510440,China;不详)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2020年第4期507-511,共5页
Chinese Journal of Public Health
